Alpha Brain Review

Alpha Brain Review

May 2, 2023

Does Alpha Brain really work? In this Alpha Brain review, we'll explore the benefits, ingredients, dosage recommendations, and potential drawbacks of this nootropic supplement. Whether you're a student, an athlete, or just someone looking to improve your cognitive abilities, read on to find out if Alpha Brain is the right choice for you.

Alpha Brain Reviews

Overall Verdict

3.4 / 5 Stars

  • Alpha Brain is a basic nootropic offering. It's not terrible, but it isn't competitive compared to the leading nootropics on the market.
  • From our research and testing, NooCube is currently the product to beat. By combining scientific innovation and proven ingredients, NooCube stands head and shoulders above Alpha Brain in enhancing cognitive function and promoting brain health.
  • NooCube's superior formulation is grounded in the latest neuroscientific research, incorporating a blend of all-natural ingredients that work synergistically to unlock the full potential of your brain. NooCube is effective in bolstering memory and focus, as well as elevating creativity and mental agility.
Best Alternative To Onnit Alpha Brain

Introduction To Alpha Brain, Onnit's Nootropic Endorsed by Joe Rogan

In today's fast-paced world, many people struggle with mental fog and scattered thoughts, which can hinder productivity and daily life. Consequently, individuals are turning to nootropic supplements to enhance productivity, mood, focus, and overall cognitive performance.

Alpha Brain, a well-known nootropic supplement formulated by Onnit Labs, has garnered considerable attention over the years. While some individuals, like Joe Rogan, swear by its efficacy, others remain skeptical. This article aims to delve into the scientific basis behind Alpha Brain, assess its safety, potential side effects, and evaluate alternatives.

Onnit Labs, the brand behind Alpha Brain, was established by entrepreneur and author Aubrey Marcus in 2010, is headquartered in Austin, Texas. Marcus, an advocate of holistic health, envisions optimizing human capabilities through exercise, nutrition, and supplementation.

Alpha Brain's Relationship with Joe Rogan

Joe Rogan, a prominent supporter of Alpha Brain, credits the supplement for improving his recall of words and sentence formation. This has led to a strong association between Rogan and Alpha Brain.

Joe Rogan's Claims

  • "I always take Alpha Brain" 
  • "I feel like I don't want to do anything without it"
  • "It makes word recall easier, I feel like I'm one step ahead"
  • "Everyone I've given this to has the same result"

Benefits of Alpha Brain

Onnit's Claimed Benefits

Alpha Brain claims to offer numerous benefits, including:

  • Assisting mental processing
  • Boosting mental performance
  • Being caffeine-free to prevent jitters
  • Facilitating flow state
  • Enhancing focus
  • Supporting memory
  • Combating brain fog

Does Alpha Brain deliver on its promises or do the negative reviews hold merit?

Our Experience With Alpha Brain

We tested Alpha Brain for 4 weeks and found no perceivable improvements in any of the areas listed above.

Research And Evidence

Questionable Research Methodologies

Although some ingredients in Alpha Brain have been linked to improved cognitive functions in humans, much of the research has been conducted on animals or in vitro. Complicating matters, many of Alpha Brain's ingredients are obscured by proprietary blends, making it difficult to gauge their effectiveness.

This suggests that Alpha Brain's claims of supporting cognitive functions, memory, and focus may be overstated.

Onnit Alpha Brain Clinical Trials
A 2016 randomized controlled trial reported that after six weeks, Alpha Brain significantly improved verbal memory in healthy adults compared to controls. However, several factors undermine the credibility of these findings:

The study was funded by Onnit, the creator of Alpha Brain, which introduces potential bias.
No other trials or scientific papers have corroborated the results. Repeatability is a cornerstone of scientific discovery, and the lack of replication raises questions about the findings.

The study's conclusion highlights the need for additional research.

Ingredients - Ineffective Dosages in Alpha Brain

Surprisingly, this detailed review of Onnit's Alpha Brain reveals that crucial nootropics are included in insufficient dosages to be effective.

Alpha Brain contains a range of natural ingredients, including acetyl-L-carnitine, Bacopa monnieri, oat straw extract, phosphatidylserine, and others. These ingredients can be effective nootropic ingredients:

Acetyl-L-carnitine is an amino acid that plays a crucial role in cellular metabolism and energy production. According to a review of several studies, acetyl-L-carnitine may improve cognitive function in individuals with mild cognitive impairment and age-related memory decline (1). The effective dosage of acetyl-L-carnitine is between 500 to 2,000 mg per day (2).

Bacopa monnieri is an herb commonly used in traditional Ayurvedic medicine for its potential cognitive-enhancing effects. According to a systematic review, Bacopa monnieri may improve cognitive function, particularly memory and attention (3). The effective dosage of Bacopa monnieri is between 300 to 450 mg per day (4).

Oat straw extract, derived from the aerial parts of the oat plant, is rich in flavonoids and has been used traditionally to improve cognitive function. According to a randomized, double-blind, placebo-controlled study, oat straw extract may improve cognitive performance in healthy adults (5). The effective dosage of oat straw extract is between 800 to 1600 mg per day (6).

Phosphatidylserine is a phospholipid that plays a crucial role in cellular membrane function and communication. According to a review of several studies, phosphatidylserine may improve cognitive function, particularly memory, attention, and executive function (7). The effective dosage of phosphatidylserine is between 300 to 600 mg per day (8).

Alpha Brain Ingredients Label

Overall: 3.4 / 5 Stars

Responsive Table
Test Result
Attention 3.8
Cognition 3.6
Memory 3.2
Mood 3.0
Stress 3.3
Brain Health 3.1
Learning 3.5
Overall 3.4/5


  • Well rounded ingredient profile
  • Inclusion of phosphatidylserine, recognized by FDA as effective at boosting cognition


  • Unproven claims
  • Inclusion of ingredients not recognized for their claimed effects on cognitive performance

Potential Side Effects of Alpha Brain

Most ingredients in Alpha Brain are deemed safe for the majority of users. However, some may cause mild side effects, such as headaches, nausea, and dizziness, particularly in high dosages. In case of severe side effects, discontinue use and consult a physician.

Main problems experienced with Alpha Brain

  • Mild Headaches:
    Scientifically termed cephalalgia, mild headaches are a common side effect experienced by some Alpha Brain users. These headaches might be due to the body's initial response to the supplement's potent ingredients.
  • Gastrointestinal Discomfort:
    Digestive issues such as bloating, flatulence, or stomach cramps (technically known as dyspepsia) may occur when taking Alpha Brain. These discomforts are often transient and subside as the body adjusts to the supplement.
  • Sleep Pattern Changes:
    While Alpha Brain is designed to enhance cognitive function, it may inadvertently affect sleep patterns. Some users report experiencing difficulty falling asleep, or insomnia, while others report more vivid dreams or even nightmares, which are scientifically known as oneirodynia.
  • Lightheadedness or Dizziness:
    Some individuals have reported feeling lightheaded or dizzy (medically termed vertigo) after taking Alpha Brain. This reaction could be a result of the supplement's impact on blood pressure or cerebral blood flow.
  • Allergic Reactions:
    As with any dietary supplement, there's always the risk of an allergic reaction. Symptoms may include skin rash (urticaria), difficulty breathing (dyspnea), or swelling of the face, lips, or tongue (angioedema). If you experience any of these symptoms, discontinue use immediately and consult a healthcare professional.
  • Nervousness or Jitters:
    Caffeine and stimulants can cause excessive stimulation leading to feelings of heightened nervousness or anxiety.

Best Alternative to Alpha Brain

If you're interested in nootropics that provide brain health support, greater mood enhancement properties and memory support there are better options than Alpha Brain. The best overall nootropic in our view is NooCube.

NooCube vs Vyvamind


4.8 / 5

Unlike Alpha Brain, NooCube is formulated to improve multiple aspects of cognitive function, including memory, focus, and mental clarity. It contains a wider range of ingredients than Alpha Brain, including Alpha GPC, Huperzine A, and Bacopa Monnieri, which have been extensively studied and shown to have significant cognitive benefits.

Alpha Brain contains some promising ingredients, but it's primarily focused on energy and alertness. Overall, Noocube is a more comprehensive and evidence-based nootropic supplement than Alpha Brain.


So, wrapping things up, when it comes to nootropics, Alpha Brain is kind of like the "Goldilocks" of the bunch. It's not the best, but it's definitely not the worst either. It can support brain health and provide some degree of cognitive enhancement, but it's worth checking out some of the more cutting-edge options out there before deciding whether you really want to jump on the Alpha Brain train.

Don't worry, though; we've got you covered with our top-notch guide on the best nootropics out there. This will help you find the perfect fit for your needs, whether you're after a mental boost for work or looking to improve focus and memory. Just remember, what right for one person might not be the best options for you, so read on and find your own "brain fuel." Our top recommendation is NooCube, the most comprehensively formulated product grounded in the latest research.


Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

Popular nootropic supplements include NooCube, Mind Lab Pro, and Vyvamind. NooCube contains a blend of ingredients that may improve memory, focus, and overall cognitive function. Mind Lab Pro is designed to support brain health and cognitive performance through a variety of ingredients, including vitamins, minerals, and plant-based compounds. Vyvamind is a premium nootropic supplement that focuses almost exlcusively on cognitive function and mental performance. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.


  1. Pettegrew, J. W., Levine, J., McClure, R. J. (2000). Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular psychiatry, 5(6), 616-632.
  2. National Institutes of Health. (2022). Acetyl-L-carnitine. In Dietary Supplements Fact Sheets. Retrieved from
  3. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., Norman Scholfield, C. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528-535.
  4. National Institutes of Health. (2022). Bacopa. In Dietary Supplements Fact Sheets. Retrieved from
  5. Kennedy, D. O., Jackson, P. A., Forster, J., Khan, J., Grothe, T., Perrinjaquet-Moccetti, T., ... & Haskell-Ramsay, C. F. (2018). Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial.