NooCube vs Alpha Brain - Which Is Right For You?

Alpha Brain vs NooCube Which Is Best

February 19, 2024

In this article we're directly testing and comparing NooCube vs Alpha Brain. In the competitive world of nootropic supplements, choosing the right product to enhance cognitive function can be daunting. This review takes a closer look at two leading options: NooCube, from Wolfson Brands Ltd, and Alpha Brain, developed by Onnit Labs Inc. Both brands have carved out significant spaces in the market, promising improved mental clarity, focus, and memory. However, what sets them apart, and how do their claims hold up under scrutiny?

Our analysis is particularly timely, as it coincides with the release of NooCube's brand new formulation in February 2024. This updated version promises an even more potent blend of ingredients, designed to optimize cognitive performance more effectively than ever before. We will test both products directly, comparing their effects on cognitive enhancement. This comparison will not only cover their claims and marketing but will delve deep into the scientific backing of their chosen ingredients and the dosages of each.

By examining ingredients like NooCube's LuteMax 2020, Bacopa Monnieri, and the newly added Panax Ginseng, against Alpha Brain's proprietary blends and key ingredients like Bacopa Monniera and Huperzia Serrata.

Overall Verdict

Alpha Brain

2.9 / 5 Stars

Alpha Brain vs

NooCube - Winner

4.9/ 5 Stars

NooCube vs Alpha Brain Review
  • Alpha Brain is a basic nootropic offering. It's not terrible, but it isn't competitive compared to the leading nootropics on the market.
  • From our research and testing, NooCube is currently the product to beat. By combining scientific innovation and proven ingredients, NooCube stands head and shoulders above Alpha Brain in enhancing cognitive function and promoting brain health.
  • NooCube's updated formulation was launched in February 2024, and is grounded in the latest neuroscientific research, incorporating a blend of all-natural ingredients that work synergistically to unlock the full potential of your brain. NooCube is effective in bolstering memory and focus, as well as elevating creativity and mental agility.

Introduction To Alpha Brain And NooCube

When we're talking about Alpha Brain and NooCube, we're not just comparing two products. We're also comparing two companies, each with its own ethos, reputation, and approach to cognitive enhancement. Let's dive into who's behind these brain-boosting formulas.

On one side, we have Onnit Labs, the maker of Alpha Brain. Based in Austin, Texas, Onnit is a health and wellness company that hit the ground running in 2010. It's known for its holistic approach to human optimization, offering everything from fitness equipment to supplements like Alpha Brain. Onnit has a firm foot in scientific research, and they've partnered with medical professionals and institutions to validate the effectiveness of their products.

A name often associated with Alpha Brain is Joe Rogan, the comedian, podcaster, and UFC commentator. He's been a vocal proponent of the supplement since its early days, citing its benefits to mental clarity and focus. It's important to note, however, that Rogan is more than just a fan – he's a stakeholder. He's been involved with Onnit from the beginning, contributing to its product development and serving as a brand ambassador.

On the other side of the ring, we have NooCube, manufactured by Wolfson Berg Limited. This Cyprus-based company has carved out a niche for itself in the health supplement industry over the past decade. Their focus is on creating safe, natural supplements that enhance cognitive functioning. NooCube is one such product, and the company prides itself on its formulation's scientific backing.

Unlike Onnit, Wolfson Berg doesn't have a celebrity spokesperson. Instead, they let their products do the talking, relying on a blend of natural ingredients, scientific research, and positive customer testimonials to make their case.

Whether you're drawn to the celebrity-endorsed, research-backed philosophy of Onnit, or the natural, science-focused approach of Wolfson Berg, is a matter of personal preference. As we dive deeper into the ingredients and effects of Alpha Brain and NooCube, you'll get a clearer picture of which might be the right fit for you.

Benefits of Alpha Brain And NooCube

Onnit's Claimed Benefits

Alpha Brain is designed to work synergistically, boosting mental acuity. It operates primarily by enhancing acetylcholine levels, thus bolstering memory and learning abilities, while also augmenting overall mental clarity and focus. The effects usually manifest within 1-2 hours and last up to 3 hours. However, the effects might not be apparent for some people, possibly due to lower doses or individual sensitivity. The supplement is primarily used as a cognitive enhancer, often aiding students during exams or professionals needing to be 'on their game' for critical presentations. It's also touted as an effective tool for improving memory recall. Alpha Brain comprises 3 proprietary blends designed to promote Alpha wave synthesis, stimulate Acetylcholine production, and balance neurotransmitters, which are all crucial for cognitive function.

NooCube's Claimed Benefits

NooCube, on the other hand, is a potent, all-natural nootropic blend designed to dramatically boost memory power and focus over time. It operates by increasing the secretion of neurotransmitters such as dopamine and serotonin, thereby enhancing focus, concentration, and mood. It also sparks the release of neurotransmitters that allow your brain to absorb and retain more information, consequently improving memory and general cognition[10]. Additionally, NooCube can improve mood by boosting serotonin levels in the brain and inducing dopamine release, which increases motivation11. NooCube's effects usually kick in after 2 hours of ingestion and can last up to 24 hours, with the recommendation of a 6-week daily intake to fully experience all the benefits. It consists of 12 effective ingredients that work together to enhance cognitive function without causing any unwanted side effects. People who take NooCube daily generally see benefits such as enhanced concentration levels, focus, memory and cognitive ability, improved multitasking capabilities, increased learning capacity, boosted brain energy, and an enhanced mood. The latest iteration of NooCube's formulation adds new ingredients and has removed those that some individuals may have some sensitivity to, namely oat straw and huperzine A.

Research And Evidence

Alpha Brain and NooCube, offer unique blends of ingredients aimed at optimizing mental acuity. However, a closer examination of their research and ingredient lists reveals some interesting contrasts.

Alpha Brain, developed by Onnit, includes a combination of vitamins, minerals, and herbs designed to enhance cognitive function, memory recall, focus, and concentration. The supplement aims to increase acetylcholine levels, a neurotransmitter involved in learning and memory, and support alpha brain waves associated with mental clarity and focus. However, the credibility of Alpha Brain's research methodologies has been questioned. Much of the research supporting its ingredients has been conducted on animals or in vitro, which doesn't necessarily translate to the same effects in humans. Furthermore, Alpha Brain obscures many of its ingredients within proprietary blends, making it difficult to assess their individual effectiveness. This lack of transparency raises questions about the validity of Alpha Brain's cognitive enhancement claims.

A 2016 randomized controlled trial sponsored by Onnit reported that Alpha Brain significantly improved verbal memory in healthy adults after six weeks. However, this finding has been criticized on several fronts. Firstly, the trial was funded by Onnit, potentially introducing bias. Secondly, no other trials or scientific papers have corroborated these results. Repeatability is a cornerstone of scientific discovery, and the lack of replication raises questions about the trial's findings. Lastly, the conclusion of the study itself emphasized the need for additional research, implying that the findings were not definitive.

On the other hand, NooCube offers a blend of nine natural ingredients, designed to enhance cognitive function, memory, concentration, and motivation. It works by increasing the secretion of neurotransmitters like dopamine and serotonin, which can enhance focus, mood, and motivation. The supplement also improves memory by stimulating the production of acetylcholine in the brain. NooCube's effects usually kick in after about 2 hours and can last up to 24 hours. It is designed to be taken daily, with full effects typically experienced after 6 weeks of daily use.

Unlike Alpha Brain, NooCube discloses the individual ingredients in its blend, which consist of clinically proven nootropic components. This transparency allows for a better understanding of the effects and potential benefits of NooCube. However, while NooCube uses established nootropic ingredients, comprehensive scientific studies directly assessing the blend as a whole are still needed to fully validate its claims.

While both Alpha Brain and NooCube offer potential cognitive benefits, they differ in terms of research transparency and ingredient disclosure. This examination underscores the importance of critical evaluation when considering nootropic supplements.

Ingredients - Ineffective Dosages in Alpha Brain

Alpha Brain Ingredients (click to reveal)

  • Vitamin B6 (Pyridoxine HCl)
  • Onnit Flow Blend (650 mg): This proprietary blend consists of Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract.
  • Onnit Focus Blend (240 mg): This blend includes Alpha GPC, Bacopa Monniera, and Huperzia Serrata
  • Onnit Fuel Blend (65 mg): This blend comprises L-Leucine, Vinpocetine, and Pterostilbene
  • L-Tyrosine
  • L-Theanine
  • Phosphatidylserine
  • Alpha GPC
  • Bacopa Monniera
  • Huperzia Serrata
  • Oat Straw Extract
  • Vinpocetine
  • Pterostilbene

NooCube Ingredients (click to reveal)

  • LuteMax 2020
  • Bacopa Monnieri (250mg)
  • Panax Ginseng 200:1 Concentrate (20mg)
  • Pterostilbene (140mcg)
  • Resveratrol (14.3mg)
  • L-theanine (100mg)
  • L-tyrosine (250mg)
  • Choline (250mg)
  • Cat’s Claw 4:1 Concentrate
  • Vitamin B1 (1.1mg)
  • Vitamin B7 (50mcg)
  • Vitamin B12 (2.5mcg)

When we closely examine the ingredient profiles of these two supplements, striking differences emerge, particularly in their dosages and transparency.

Alpha Brain features a composition that heavily relies on proprietary blends - the Onnit Flow, Focus, and Fuel blends. The use of these blends is a bone of contention as it masks the individual dosages of the components, making it challenging to ascertain their effectiveness. For instance, the Onnit Flow Blend comprises 650mg, but we don't know the specific amount of each ingredient - Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract - it contains.

NooCube, on the other hand, opts for a more straightforward approach, clearly stating the amount of each ingredient. For example, it contains 250mg of Bacopa Monnieri and 20mg of Huperzine A. This transparency allows users to understand exactly what they're consuming, aligning with the principles of evidence-based medicine.

However, Alpha Brain is not entirely without merit. It incorporates several ingredients known for their cognitive-enhancing effects, such as L-Tyrosine, L-Theanine, and Phosphatidylserine. The drawback lies in their undisclosed dosages within the proprietary blends, which potentially undermines their efficacy.

NooCube utilizes similar ingredients but discloses the exact amounts. For instance, it contains L-theanine and L-tyrosine at 100mg and 250mg, respectively, reflecting the dosages found to be effective in scientific studies(1,2).

Alpha Brain's usage of Alpha GPC, Bacopa Monniera, Huperzia Serrata, and Vinpocetine within blends also raises concerns about under-dosing. These ingredients have demonstrated nootropic benefits at specific dosages(3,4,5), which are difficult to confirm within Alpha Brain’s proprietary mixtures. Conversely, NooCube provides a dose of 50mg of Alpha GPC, while the amounts of Bacopa Monnieri, Huperzine A, and Pterostilbene are explicitly stated.

While both Alpha Brain and NooCube contain ingredients with potential cognitive benefits, the lack of transparency in Alpha Brain's proprietary blends makes it difficult to assess their true efficacy. NooCube's transparent approach, disclosing the precise dosages of each ingredient, aligns more closely with the tenets of scientific research and offers users a clearer understanding of what they're consuming.

Potential Side Effects of Alpha Brain And NooCube

When considering the possible side effects of Alpha Brain and NooCube, it is important to note that both products are generally well-tolerated, and any side effects reported are rare and mild in nature. However, it is still crucial to be aware of the potential effects to make an informed decision.

Alpha Brain contains various ingredients, such as Bacopa Monniera, Huperzia Serrata, and Vinpocetine. While these ingredients have been generally regarded as safe, some individuals may experience mild gastrointestinal discomfort, such as nausea or stomach upset, when taking Bacopa Monniera(6). Huperzia Serrata, another component of Alpha Brain, has been associated with mild digestive issues and potential allergic reactions in rare cases(7). Vinpocetine, found in the Onnit Fuel Blend, may rarely cause mild side effects such as headaches, dizziness, or gastrointestinal disturbances(8).

On the other hand, NooCube incorporates ingredients like Bacopa Monnieri and Panax Ginseng. Similar to Alpha Brain, Bacopa Monnieri may cause mild gastrointestinal discomfort in some individuals(9).

Both products also contain L-Theanine and L-Tyrosine. These ingredients are considered safe, with minimal reported side effects. L-Theanine, an amino acid commonly found in tea, is generally well-tolerated, and any side effects are infrequent and mild(10). L-Tyrosine is also well-tolerated, with rare reports of gastrointestinal issues or headaches(11). Alpha GPC is present in Alpha Brain - it's a precursor to acetylcholine, has demonstrated good tolerability, with occasional reports of mild side effects like digestive discomfort or skin rash(12).


If you're interested in nootropics that provide brain health support, greater mood enhancement properties and memory support there are better options than Alpha Brain. The best overall nootropic in our view is NooCube.

Alpha Brain vs NooCube Comparison

Winner - NooCube

4.9 / 5

After directly comparing Alpha Brain and NooCube, it's clear that NooCube is better designed to enhance all aspects of cognitive function, including memory, focus, and mental clarity. It offers a wider selection of ingredients, including Alpha GPC, Panax Ginseng, and Bacopa Monnieri, which have been extensively studied and proven to provide significant cognitive benefits.

While Alpha Brain does have some promising ingredients, its main focus is on boosting energy and alertness. In contrast, NooCube takes a more comprehensive and evidence-based approach to nootropic supplementation, targeting multiple cognitive functions whilst also supporting overall brain health.


Compared to Alpha Brain, NooCube offers a more comprehensive and well-rounded approach to nootropic supplementation. Its ingredient profile includes a carefully selected blend of clinically proven nootropic compounds, each serving a specific purpose in promoting cognitive function and mental well-being.

NooCube's formula incorporates powerful ingredients such as Bacopa Monnieri, Huperzine A, and Alpha GPC, which have been extensively studied and shown to provide notable cognitive benefits. These ingredients work synergistically to enhance memory, focus, and overall brain health.

NooCube is formulated with precision and transparency, clearly listing the exact dosages of each ingredient. This level of transparency allows users to understand the potency and effectiveness of the product. In contrast, Alpha Brain's use of proprietary blends and undisclosed dosages raises concerns about under-dosing and inhibits the ability to evaluate the true efficacy of its ingredients. NooCube's carefully selected ingredients are also well-tolerated, and any reported side effects are generally mild and infrequent. 

NooCube's emphasis on clinically proven ingredients at effective dosages sets it apart as a top-tier nootropic supplement for those seeking enhanced brain function, mood enhancement, and memory support.


Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

Popular nootropic supplements include NooCube, Mind Lab Pro, and Vyvamind. NooCube contains a blend of ingredients that may improve memory, focus, and overall cognitive function. Mind Lab Pro is designed to support brain health and cognitive performance through a variety of ingredients, including vitamins, minerals, and plant-based compounds. Vyvamind is a premium nootropic supplement that focuses almost exlcusively on cognitive function and mental performance. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.


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