NooCube vs Alpha Brain - Which Is Right For You?

Alpha Brain vs NooCube Which Is Best

February 15, 2025

In this article, we're comparing NooCube vs Alpha Brain. Over the past 12 months, we put both supplements to the test to see which one really boosts cognitive function. With so many nootropics on the market, choosing the right one can be tough. We focused on two well-known options: NooCube by Wolfson Brands and Alpha Brain by Onnit Labs, both claiming to improve mental clarity, focus, and memory. But what truly sets them apart, and do their claims hold up?

Our review is timely as NooCube updated its formula in February 2024. We used the new version for our testing period, giving us fresh insights into its performance. NooCube now claims to offer an even more powerful mix of ingredients for better cognitive enhancement. We tested both supplements side by side, not only checking their marketing claims but also examining the science behind their ingredients and dosages.

We took a close look at each formula, comparing NooCube’s LuteMax 2020, Bacopa Monnieri, and the new Panax Ginseng with Alpha Brain’s blend, which includes Bacopa Monnieri and Huperzia Serrata. Our goal is to give you a clear picture of how effective each product is based on our year-long testing, so you can decide which one might be best for you.

Overall Verdict

Alpha Brain


2.6 / 5 Stars


Alpha Brain vs

NooCube


3.7/ 5 Stars


NooCube vs Alpha Brain Review
  • Alpha Brain is a basic nootropic offering. It's not terrible, but it isn't competitive compared to the leading nootropics on the market. Our main issue with the product stems from the brand's lack of trasnparency and hidden underdosing issues.
  • From our research and testing, NooCube is marginally better in enhancing cognitive function and promoting brain health.
  • Recommendation: The top performing nootropic supplement we've tested is ThinkEase. We liked that its formulation is grounded in the latest neuroscientific research, incorporating a blend of all-natural ingredients that work synergistically to unlock the full potential of your brain. We found ThinkEase to be effective in boosting memory and focus, as well as improving creativity and mental agility.
NooCube vs Alpha Brain alternative

Introduction To Alpha Brain And NooCube

When discussing Alpha Brain and NooCube, we're comparing not just the products but also the companies behind them, each with its unique philosophy and reputation in cognitive enhancement. Let's examine the origins and methodologies of these brain-boosting formulas.

Onnit Labs, the creator of Alpha Brain, is based in Austin, Texas. Established in 2010, Onnit is renowned for its comprehensive approach to human optimization, offering a range of products from fitness equipment to supplements like Alpha Brain. Onnit emphasizes scientific research, collaborating with medical experts and institutions to substantiate their product's efficacy.

A prominent figure associated with Alpha Brain is Joe Rogan, the comedian, podcaster, and UFC commentator. Rogan has been an outspoken advocate of the supplement from its early days, highlighting its benefits for mental clarity and focus. More than just a fan, Rogan is a stakeholder in Onnit, actively participating in product development and serving as a brand ambassador.

In contrast, NooCube is produced by Wolfson Brands Limited, a company based in Cyprus that has established a solid reputation in the health supplement industry over the past decade. Their focus is on creating safe, natural supplements designed to enhance cognitive function. NooCube exemplifies this commitment, with its formulation supported by scientific research.

Unlike Onnit, Wolfson Berg does not rely on celebrity endorsements. Instead, they emphasize the quality and effectiveness of their products, using a blend of natural ingredients, scientific backing, and positive customer reviews to build their reputation.

At a superficial level, deciding between the celebrity-endorsed, research-driven approach of Onnit and the natural, science-based methodology of Wolfson Brands ultimately depends on personal preference. As we further explore the ingredients and effects of Alpha Brain and NooCube, our extended 12-month test results will offer a clearer understanding of which supplement might suit you best.

Benefits of Alpha Brain And NooCube

Onnit's Claimed Benefits

Alpha Brain is designed to work synergistically, boosting mental acuity. It operates primarily by enhancing acetylcholine levels, thus bolstering memory and learning abilities, while also augmenting overall mental clarity and focus. The effects usually manifest within 1-2 hours and last up to 3 hours. However, the effects might not be apparent for some people, possibly due to lower doses or individual sensitivity. The supplement is primarily used as a cognitive enhancer, often aiding students during exams or professionals needing to be 'on their game' for critical presentations. It's also touted as an effective tool for improving memory recall. Alpha Brain comprises 3 proprietary blends designed to promote Alpha wave synthesis, stimulate Acetylcholine production, and balance neurotransmitters, which are all crucial for cognitive function.

NooCube's Claimed Benefits

NooCube, on the other hand, is a potent, all-natural nootropic blend designed to dramatically boost memory power and focus over time. It operates by increasing the secretion of neurotransmitters such as dopamine and serotonin, thereby enhancing focus, concentration, and mood. It also sparks the release of neurotransmitters that allow your brain to absorb and retain more information, consequently improving memory and general cognition[10]. Additionally, NooCube can improve mood by boosting serotonin levels in the brain and inducing dopamine release, which increases motivation11. NooCube's effects usually kick in after 2 hours of ingestion and can last up to 24 hours, with the recommendation of a 6-week daily intake to fully experience all the benefits. It consists of 12 effective ingredients that work together to enhance cognitive function without causing any unwanted side effects. People who take NooCube daily generally see benefits such as enhanced concentration levels, focus, memory and cognitive ability, improved multitasking capabilities, increased learning capacity, boosted brain energy, and an enhanced mood. The latest iteration of NooCube's formulation adds new ingredients and has removed those that some individuals may have some sensitivity to, namely oat straw and huperzine A.

Research And Evidence

Alpha Brain and NooCube, offer unique blends of ingredients aimed at optimizing mental acuity. However, a closer examination of their research and ingredient lists reveals some interesting contrasts.

Alpha Brain, developed by Onnit, includes a combination of vitamins, minerals, and herbs designed to enhance cognitive function, memory recall, focus, and concentration. The supplement aims to increase acetylcholine levels, a neurotransmitter involved in learning and memory, and support alpha brain waves associated with mental clarity and focus. However, the credibility of Alpha Brain's research methodologies has been questioned. Much of the research supporting its ingredients has been conducted on animals or in vitro, which doesn't necessarily translate to the same effects in humans. Furthermore, Alpha Brain obscures many of its ingredients within proprietary blends, making it difficult to assess their individual effectiveness. This lack of transparency raises questions about the validity of Alpha Brain's cognitive enhancement claims.

A 2016 randomized controlled trial sponsored by Onnit reported that Alpha Brain significantly improved verbal memory in healthy adults after six weeks. However, this finding has been criticized on several fronts. Firstly, the trial was funded by Onnit, potentially introducing bias. Secondly, no other trials or scientific papers have corroborated these results. Repeatability is a cornerstone of scientific discovery, and the lack of replication raises questions about the trial's findings. Lastly, the conclusion of the study itself emphasized the need for additional research, implying that the findings were not definitive.

On the other hand, NooCube offers a blend of nine natural ingredients, designed to enhance cognitive function, memory, concentration, and motivation. It works by increasing the secretion of neurotransmitters like dopamine and serotonin, which can enhance focus, mood, and motivation. The supplement also improves memory by stimulating the production of acetylcholine in the brain. NooCube's effects usually kick in after about 2 hours and can last up to 24 hours. It is designed to be taken daily, with full effects typically experienced after 6 weeks of daily use.

Unlike Alpha Brain, NooCube discloses the individual ingredients in its blend, which consist of clinically proven nootropic components. This transparency allows for a better understanding of the effects and potential benefits of NooCube. However, while NooCube uses established nootropic ingredients, comprehensive scientific studies directly assessing the blend as a whole are still needed to fully validate its claims.

While both Alpha Brain and NooCube offer potential cognitive benefits, they differ in terms of research transparency and ingredient disclosure. This examination underscores the importance of critical evaluation when considering nootropic supplements.

Ingredients - Ineffective Dosages in Alpha Brain

Alpha Brain Ingredients (click to reveal)

  • Vitamin B6 (Pyridoxine HCl)
  • Onnit Flow Blend (650 mg): This proprietary blend consists of Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract.
  • Onnit Focus Blend (240 mg): This blend includes Alpha GPC, Bacopa Monniera, and Huperzia Serrata
  • Onnit Fuel Blend (65 mg): This blend comprises L-Leucine, Vinpocetine, and Pterostilbene
  • L-Tyrosine
  • L-Theanine
  • Phosphatidylserine
  • Alpha GPC
  • Bacopa Monniera
  • Huperzia Serrata
  • Oat Straw Extract
  • Vinpocetine
  • Pterostilbene

NooCube Ingredients (click to reveal)

  • LuteMax 2020
  • Bacopa Monnieri (250mg)
  • Panax Ginseng 200:1 Concentrate (20mg)
  • Pterostilbene (140mcg)
  • Resveratrol (14.3mg)
  • L-theanine (100mg)
  • L-tyrosine (250mg)
  • Choline (250mg)
  • Cat’s Claw 4:1 Concentrate
  • Vitamin B1 (1.1mg)
  • Vitamin B7 (50mcg)
  • Vitamin B12 (2.5mcg)

When we closely examine the ingredient profiles of these two supplements, striking differences emerge, particularly in their dosages and transparency.

Alpha Brain features a composition that heavily relies on proprietary blends - the Onnit Flow, Focus, and Fuel blends. The use of these blends is a bone of contention as it masks the individual dosages of the components, making it challenging to ascertain their effectiveness. For instance, the Onnit Flow Blend comprises 650mg, but we don't know the specific amount of each ingredient - Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract - it contains.

NooCube, on the other hand, opts for a more straightforward approach, clearly stating the amount of each ingredient. For example, it contains 250mg of Bacopa Monnieri and 20mg of Huperzine A. This transparency allows users to understand exactly what they're consuming, aligning with the principles of evidence-based medicine.

However, Alpha Brain is not entirely without merit. It incorporates several ingredients known for their cognitive-enhancing effects, such as L-Tyrosine, L-Theanine, and Phosphatidylserine. The drawback lies in their undisclosed dosages within the proprietary blends, which potentially undermines their efficacy.

NooCube utilizes similar ingredients but discloses the exact amounts. For instance, it contains L-theanine and L-tyrosine at 100mg and 250mg, respectively, reflecting the dosages found to be effective in scientific studies(1,2).

Alpha Brain's usage of Alpha GPC, Bacopa Monniera, Huperzia Serrata, and Vinpocetine within blends also raises concerns about under-dosing. These ingredients have demonstrated nootropic benefits at specific dosages(3,4,5), which are difficult to confirm within Alpha Brain’s proprietary mixtures. Conversely, NooCube provides a dose of 50mg of Alpha GPC, while the amounts of Bacopa Monnieri, Huperzine A, and Pterostilbene are explicitly stated.

While both Alpha Brain and NooCube contain ingredients with potential cognitive benefits, the lack of transparency in Alpha Brain's proprietary blends makes it difficult to assess their true efficacy. NooCube's transparent approach, disclosing the precise dosages of each ingredient, aligns more closely with the tenets of scientific research and offers users a clearer understanding of what they're consuming.

Potential Side Effects of Alpha Brain And NooCube

When considering the possible side effects of Alpha Brain and NooCube, it is important to note that both products are generally well-tolerated, and any side effects reported are rare and mild in nature. However, it is still crucial to be aware of the potential effects to make an informed decision.

Alpha Brain contains various ingredients, such as Bacopa Monniera, Huperzia Serrata, and Vinpocetine. While these ingredients have been generally regarded as safe, some individuals may experience mild gastrointestinal discomfort, such as nausea or stomach upset, when taking Bacopa Monniera(6). Huperzia Serrata, another component of Alpha Brain, has been associated with mild digestive issues and potential allergic reactions in rare cases(7). Vinpocetine, found in the Onnit Fuel Blend, may rarely cause mild side effects such as headaches, dizziness, or gastrointestinal disturbances(8).

On the other hand, NooCube incorporates ingredients like Bacopa Monnieri and Panax Ginseng. Similar to Alpha Brain, Bacopa Monnieri may cause mild gastrointestinal discomfort in some individuals(9).

Both products also contain L-Theanine and L-Tyrosine. These ingredients are considered safe, with minimal reported side effects. L-Theanine, an amino acid commonly found in tea, is generally well-tolerated, and any side effects are infrequent and mild(10). L-Tyrosine is also well-tolerated, with rare reports of gastrointestinal issues or headaches(11). Alpha GPC is present in Alpha Brain - it's a precursor to acetylcholine, has demonstrated good tolerability, with occasional reports of mild side effects like digestive discomfort or skin rash(12).

Recommendation

If you're interested in nootropics that provide brain health support, greater mood enhancement properties and memory support there are better options than Alpha Brain. The best overall nootropic in our view is ThinkEase.

Alpha Brain


2.6 / 5 Stars


Alpha Brain vs

NooCube


3.7/ 5 Stars


NooCube vs Alpha Brain Review
  • Alpha Brain is a basic nootropic offering. It's not terrible, but it isn't competitive compared to the leading nootropics on the market. Our main issue with the product stems from the brand's lack of trasnparency and hidden underdosing issues.
  • From our research and testing, NooCube is marginally better in enhancing cognitive function and promoting brain health.
  • Recommendation: The top performing nootropic supplement we've tested is ThinkEase. We liked that its formulation is grounded in the latest neuroscientific research, incorporating a blend of all-natural ingredients that work synergistically to unlock the full potential of your brain. We found ThinkEase to be effective in boosting memory and focus, as well as improving creativity and mental agility.
NooCube vs Alpha Brain alternative

Conclusion

After testing both NooCube and Alpha Brain over a 12-month period, we found NooCube to be the slightly more reliable of the two. The ingredients are generally well-tolerated, and side effects are uncommon and mild when they do occur. But while NooCube outperforms Alpha Brain in most areas, it doesn't match the top performing nootropic supplement in our tests, ThinkEase.

ThinkEase offers everything NooCube does—but with an even more advanced and well-rounded formula. It includes key cognitive enhancers that NooCube leaves out, such as Citicoline and Acetyl L-Carnitine, all dosed effectively and supported by strong clinical evidence. In our experience, ThinkEase provided sharper focus, faster recall, and better mental stamina—with consistent results over time.

If you're serious about improving your cognitive performance and want the most value for your investment, ThinkEase is the smarter, more complete choice.

FAQs

Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

ThinkEase is our top recommended nootropic supplement. It performed best during our extensive testing for improving memory, focus, and overall brain performance. For more details, check out our complete guide on the best nootropics. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.

References

  1. Owen, G. N., et al. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Psychopharmacology, 195(4), 569-577. 
  2. Jongkees, B. J., et al. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of Psychiatric Research, 70, 50-57. 
  3. Zeisel, S. H. (2012). Dietary choline: Biochemistry, physiology, and pharmacology. Annual Review of Nutrition, 32, 247-273. 
  4. Pase, M. P., et al. (2012). The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. Journal of Alternative and Complementary Medicine, 18(7), 647-652.
  5. Zhang HY, Tang XCHuperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cellsNeurosci Lett.(2000 Sep 29).
  6. Stough, C., et al. (2008). Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double‐blind placebo‐controlled randomized trial. Phytotherapy Research, 22(12), 1629-1634. 
  7. McPhee, G., & Higham, H. (2007). Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. Journal of Psychopharmacology, 21(6), 680-692.
  8. Subhan, Z., & Hindmarch, I. (1985). Psychopharmacological effects of vinpocetine in normal healthy volunteers. European Journal of Clinical Pharmacology, 28(5), 567-571. 
  9. Xu SS, Gao ZX, Weng Z, Du ZM, Xu WA, Yang JS, Zhang ML, Tong ZH, Fang YS, Chai XS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):391-5. PMID: 8701750.
  10. Nobre, A. C., et al. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17(S1), 167-168. 
  11. Young, S. N. (2007). L-tyrosine to alleviate the effects of stress? Journal of Psychiatry & Neuroscience, 32(3), 224. 
  12. Giménez, R., et al. (2016). Effects of alpha-GPC on cognition and brain oxidative stress in aged SAMP8 mice. Current Alzheimer Research, 13(11), 1129-1138.
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