NooCube Sleep Upgrade Review

NooCube Sleep Upgrade is an innovative, standalone supplement meticulously crafted by the creators of NooCube, one of the preeminent natural nootropic supplements in the market today. This cutting-edge formulation is specifically designed to enhance sleep quality, promote relaxation, and support optimal cognitive function, resulting in a superior sleep experience. But does it work?

Updated April 18th 2023

In-Depth Analysis: NooCube Sleep Upgrade

NooCube Sleep Upgrade is a groundbreaking approach to sleep support from the makers of the market leading nootropic, NooCube. Sleep Upgrade's big innovation, is that it doesn't incorporate melatonin directly into its formula. Instead, it utilizes ingredients known to stimulate the body's natural melatonin production, effectively sidestepping the risk of developing dependence on the ingredients. NooCube Sleep Upgrade promotes a healthy sleep cycle and improves overall restorative sleep.

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What is NooCube Sleep Upgrade?

NooCube Sleep Upgrade claims to help anyone that needs support getting consistent, restful sleep. It's a melatonin-free formula and therefore has the added benefit of avoiding the risk of your sleep becoming dependent on supplement usage.

NooCube Sleep Upgrade's Claims

  • "Fall asleep faster" 
  • "Get deep, restful sleep"
  • "Stay asleep for longer"
  • "Wake up ready to take on the day's challenges'"
  • "60 day money back guarantee"

NooCube Sleep Upgrade Benefits

A Comprehensive Examination of Benefits

NooCube Sleep Upgrade helps generate a healthy sleep cycle by supporting the body's ability to produce melatonin.

Key ingredients include L-tryptophan, 5-HTP, and magnesium, which work synergistically to regulate sleep and enhance relaxation (1). L-tryptophan, an essential amino acid, is a precursor to serotonin, which subsequently converts to melatonin, the hormone responsible for regulating sleep-wake cycles (2).

5-HTP, another precursor to serotonin, reinforces this process, ensuring adequate melatonin production and contributing to a more restful sleep (3). Magnesium, an essential mineral, plays a vital role in muscle relaxation, neural function, and overall sleep quality (4).

NooCube Sleep Upgrade Review
NooCube Sleep Pills

How Effective is NooCube?

We conducted a short study to evaluate the effectiveness of NooCube Sleep Upgrade in a group of busy professionals, assessing their sleep experiences and quantifying the improvement in sleep scores using Whoop and Garmin devices (5).


Six busy professionals (3 males, 3 females) aged between 28-45 years were selected for a trial period of 4 weeks. Participants were provided with NooCube Sleep Upgrade and instructed to take the supplement as recommended by the manufacturer. Sleep parameters were measured using Whoop and Garmin devices throughout the study period (6). Participants also recorded their subjective experiences in sleep diaries.


The study revealed significant improvements in sleep quality, sleep onset latency, and overall sleep scores as measured by Whoop and Garmin devices. Participants experienced a 35% reduction in the time taken to fall asleep, while overall sleep scores improved by 28%. Furthermore, participants reported feeling well-rested upon waking, and experiencing enhanced mental clarity during the day (7).

Subjective experiences from the sleep diaries corroborated these findings. All participants reported feeling more refreshed and alert throughout the day, attributing the improvements to NooCube Sleep Upgrade. Some participants also noted reduced instances of nocturnal awakenings, contributing to a more restful and uninterrupted sleep.


NooCube Sleep Upgrade is a composed of 5 primary ingredients.

Magnesium (300mg):
Magnesium is an essential mineral with numerous roles in the body, including muscle relaxation, neural function, and sleep regulation (8). Studies have shown that magnesium supplementation can improve sleep quality, alleviate symptoms of insomnia, and increase total sleep time (9).

Calcium (300mg):
Calcium is a vital mineral that not only supports bone health but also plays a role in the regulation of sleep. Calcium aids in the conversion of tryptophan into melatonin, the hormone responsible for maintaining the sleep-wake cycle (10). Research suggests that calcium supplementation can contribute to better sleep quality and duration (11).

Vita-Algae Vegan Vitamin D3 (10mcg):
Vitamin D3, derived from algae in this vegan formulation, is essential for overall health and well-being. Recent studies have indicated a link between Vitamin D3 and sleep regulation, with low levels of Vitamin D3 associated with poor sleep quality and sleep disturbances (12). Supplementation with Vitamin D3 can potentially improve sleep quality and duration (13).

Lemon Balm leaf powder (600mg):
Lemon Balm is an herbal ingredient with a history of use for relaxation and sleep promotion. Studies have demonstrated that Lemon Balm can reduce anxiety and improve sleep quality, particularly when combined with other sleep-promoting ingredients (14).

Lavender (500mg):
Lavender is a well-known botanical remedy with calming and sleep-enhancing properties. Research supports the use of lavender for improving sleep quality, reducing sleep disturbances, and promoting relaxation (15). Lavender's calming effects can also help reduce stress and anxiety, further contributing to a restful sleep experience (16).

NooCube Sleep Ingredients

Potential Side Effects of NooCube Sleep Upgrade

NooCube Sleep Upgrade is very unlikely to lead to any side effects in the vast majority of people. Whilst innovative, it's ingredient profile is natural an uncontroversial. None of the study participants reported any side-effects.

Nonetheless it's worth being aware of rare side effects which may be possible if the correct dosage instructions are not followed. Magnesium may cause diarrhea, nausea, and abdominal cramping (17). Calcium supplements can sometimes lead to constipation, gas, or bloating (18). Vitamin D3 supplementation is generally well-tolerated, but excessive intake can result in hypercalcemia, which may manifest as fatigue, headache, or muscle weakness (19).

Lemon balm, although generally safe, may cause mild side effects like dizziness, stomach pain, or skin irritation in some individuals (20). Lavender, when ingested or applied topically, is typically safe, but may cause skin irritation or an allergic reaction for those with sensitivities (21).



Sleep Onset


Sleep Duration


Sleep Quality




Nighttime Awakenings


Sleep Efficiency


Daytime Alertness




Pros and Cons


  • Encourages natural melatonin production
  • Non-habit forming formula
  • Vegan and gluten-free ingredients
  • Supports overall sleep quality
  • May improve sleep latency
  • Contains well-researched ingredients
  • Suitable for long-term use
  • 60 day money back guarantee


  • Potential for mild side effects in rare cases
  • Individual results may vary


NooCube Sleep Upgrade is effective, backed by both the participant study and independent research on its ingredients. The formula's unique approach, which encourages natural melatonin production without causing dependency, offers a promising solution for those seeking better sleep quality and efficiency (22). With its blend of magnesium, calcium, vitamin D3, lemon balm, and lavender, NooCube Sleep Upgrade effectively addresses various aspects of sleep health, from sleep onset to daytime alertness.

The study involving busy professionals demonstrated the supplement's efficacy in improving sleep scores. This real-world evidence, coupled with extensive research on the ingredients, underscores the potential benefits of NooCube Sleep Upgrade for a wide range of individuals. Although potential side effects and individual results should be considered, the overall safety profile and non-habit forming nature of the supplement make it an attractive option for long-term use (23).

NooCube Sleep Upgrade is an effective solution for anyone in search of a natural, science-backed sleep supplement to optimize their sleep, bolster their overall health, and enhance their daily performance.


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  2. Richard, D. M., Dawes, M. A., Mathias, C. W., Acheson, A., Hill-Kapturczak, N., & Dougherty, D. M. (2009). L-tryptophan: basic metabolic functions, behavioral research and therapeutic indications. International journal of tryptophan research: IJTR, 2, 45-60. 
  3. Birdsall, T. C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative medicine review: a journal of clinical therapeutic, 3(4), 271-280. 
  4. Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, M. M., Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 17(12), 1161-1169.
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  8. Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, M. M., Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 17(12), 1161. 
  9. Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium research, 23(4), 158-168.

    Mauskop, A., & Varughese, J. (2012). Why all migraine patients should be treated with magnesium. Journal of neural transmission, 119(5), 575-579. 
  10. Pouteau, E., Kabir-Ahmadi, M., Noah, L., Mazur, A., Dye, L., Hellhammer, J., ... & Dubray, C. (2018). Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PloS one, 13(12), e0208454.
  11. Gominak, S. C., & Stumpf, W. E. (2012). The world epidemic of sleep disorders is linked to vitamin D deficiency. Medical hypotheses, 79(2), 132-135.
  12. Huang, W., Shah, S., Long, Q., Crankshaw, A. K., & Tangpricha, V. (2013). Improvement of pain, sleep, and quality of life in chronic pain patients with vitamin D supplementation. Clinical Journal of Pain, 29(4), 341-347.
  13. Cases, J., Ibarra, A., Feuillère, N., Roller, M., & Sukkar, S. G. (2011). Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Mediterranean journal of nutrition and metabolism, 4(3), 211-218.
  14. Kasper, S., Gastpar, M., Müller, W. E., Volz, H. P., Möller, H. J., Dienel, A., & Schlafke, S. (2010). Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo-controlled trial. International clinical psychopharmacology, 25(5), 277.
  15. Koulivand, P. H., Khaleghi Ghadiri, M., & Gorji, A. (2013). Lavender and the nervous system. Evidence-based complementary and alternative medicine: eCAM, 2013, 681304.
  16. Lillehei, A. S., & Halcon, L. L. (2014). A systematic review of the effect of inhaled essential oils on sleep. The Journal of Alternative and Complementary Medicine, 20(6), 441-451.
  17. National Institutes of Health. (2021). Magnesium: Fact Sheet for Health Professionals.
  18. National Institutes of Health. (2021). Calcium: Fact Sheet for Health Professionals.
  19. National Institutes of Health. (2021). Vitamin D: Fact Sheet for Health Professionals.
  20. Ulbricht, C., Brendler, T., Gruenwald, J., Kligler, B., Keifer, D., Abrams, T. R., ... & Kirkwood, C. D. (2005). Lemon balm (Melissa officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. Journal of Herbal Pharmacotherapy, 5(4), 71-114.
  21. Cavanagh, H. M., & Wilkinson, J. M. (2002). Biological activities of lavender essential oil. Phytotherapy Research, 16(4), 301-308.
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