Nooceptin Review - Does It Live Up To Its Promises?

February 18, 2025

In our Nooceptin review, we take an in-depth look at this brain booster made by SAP Nutra. It promises to improve focus, memory and overall brain performance using a mix of advanced nootropic ingredients. After testing it for 12 months, we've put together a detailed review to see if Nooceptin really delivers on its promises.

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Overall Verdict

3.1 / 5 Stars

Nooceptin is a mild nootropic with a reasonable ingredient profile.
Nooceptin works moderately well as a cognitive enhancer, but overall uses too few ingredients in low doses.
Overall, it's a safe but there are better options available.
Our Recommendation: our recommnedation is to choose a more comprehensively formulated nootropic supplement. ThinkEase is the best nootropic supplement we've tested. We like that it uses 15 ingredients including Acetyl L-Carnitine and Lion's Mane, and uses clinically proven high doses.

Check ThinkEase Deals

Best Nootropics Guide

Introduction To Nooceptin

Nooceptin is a premium nootropic blend from SAP Nutra. Nooceptin's formulation contains several natural ingredients with known cognitive benefits, such as Citicoline, Rhodiola Rosea, Bacopa monnieri, L-Theanine, Ginkgo biloba, Lion's Mane, and Panax ginseng. Studies have shown that these ingredients can enhance memory, focus, mental clarity, and overall cognitive function. But these are all dosage dependent.

Cerebral Blood Flow: By amplifying blood circulation within the brain, Nooceptin aims to help brain cells receive adequate oxygen and nutrients, consequently facilitating clear and abstract thinking.
Neuronal Connectivity: Nooceptin aims to stimulate dendrite growth on neurons, resulting in reinforced connections between neurons and an overall enhancement of brainpower.
Brain Cell Development: Nooceptin aims to fosters brain protection by elevating neurotrophic factors (NTFs), which govern the rate at which new brain cells form, evolve, and mature.
Essential Neurotransmitters: Acetylcholine (ACh), a neurotransmitter crucial for cognitive functions such as focus, learning, and information processing.
Memory Retention & Retrieval: Nooceptin aims to eliminate the struggle for words or the forgetting of important details, enabling superior memory retention and swift recall.
Stress & Anxiety Resilience: Nooceptin aims to act as a shield for your brain, defending it against the detrimental consequences of stress and anxiety.

Benefits of Nooceptin

Manufacturer's Claimed Benefits

"Unique blend of nutraceutical, neurochemicals and extracts"
"100% clinical research backed"
"Improves memory retention and recall"
"Sharpens focus"
"Reduces stress & anxiety"
"Supports learning & problem solving"

Does Nooceptin Live Up To the Claims?

Nooceptin's claimed cognitive benefits:

Bolsters brain function through six main methods
Boosts memory retention and recall
Hones focus and mitigates stress and anxiety
Augments cerebral blood flow
Strengthens neuron connections
Stimulates the growth of new brain cells
Empowers you to realize your complete cognitive potential
May positively impact Alzheimer's Disease

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Research And Evidence - Test Results

A detailed scientific assessment of Nooceptin was carried out, specifically targeting pilots without children—individuals working in high-stress, high-performance environments where sustained focus and mental clarity are essential.

Given the demanding nature of their profession, pilots often experience elevated stress levels that can negatively affect performance. The study aimed to determine whether Nooceptin could meaningfully improve cognitive functioning and help manage this occupational stress.

Participants followed the standard dosage—one capsule daily—with the expectation that noticeable improvements would emerge as they went about their routines. However, in the initial week, there were no significant changes observed in either cognitive performance or stress levels, aligning with the modest claims on Nooceptin’s product label.

By the second week, some participants chose to increase their intake to the suggested three capsules daily. This adjustment led to only minor improvements, most notably in the form of slightly enhanced concentration and a mild reduction in perceived stress. These effects were described as subtle and inconsistent, with participants noting a marginal boost in task engagement and time management.

While these incremental benefits did contribute to a general sense of improved workflow and mood, the impact was far from transformative. The cognitive gains were modest at best, with participants emphasizing that any improvements were minor and slow to manifest.

On the positive side, Nooceptin was well tolerated, with only a few reports of mild nausea—typically when taken without food. Still, given the limited cognitive benefits and delayed onset of noticeable effects, the supplement did not meet expectations for high-performing professionals under pressure.

In conclusion, while Nooceptin appears to be safe and may offer minimal short-term cognitive support, its overall effectiveness is underwhelming. For those seeking meaningful enhancements in mental clarity, focus, and stress resilience, ThinkEase remains a far superior option—delivering faster, more noticeable results through a smarter, science-backed formulation.

Best Nootropics Guide

Nooceptin Ingredients

Nooceptin has a very clear and well dosed ingredient profile, featuring the most researched and clinically proven ingredients. All ingredients are at functional levels, meaning they are dosed correctly to achieve perceivable improvements in cognition.

Citicoline (as cytidine 5'-diphosphocholine, sodium). Citicoline is a naturally occurring compound that is a vital intermediate in the synthesis of phosphatidylcholine, a critical component of cell membranes. Research has shown that citicoline supplementation can improve cognitive function, memory, and attention (Alvarez et al., 1997; Fioravanti & Buckley, 2006).
Rhodiola Rosea Extract (root) (std. to 3% rosavins & 1% salidroside) 150mg. Rhodiola Rosea is an adaptogenic herb that has been shown to enhance cognitive function, reduce mental fatigue, and improve stress resistance (Darbinyan et al., 2000; Olsson et al., 2009).
Bacopa monnieri Extract (whole plant) (std. to 40% bacosides) 150 mg. Bacopa monnieri is a traditional Ayurvedic herb known for its cognitive-enhancing properties. Studies have shown that it can improve memory, learning, and attention (Stough et al., 2001; Calabrese et al., 2008).
L-Theanine (L-γ-glutamylethylamide) 200mg. L-Theanine is an amino acid found primarily in green tea. It has been shown to promote relaxation, reduce stress, and improve focus and attention (Nobre et al., 2008; Kimura et al., 2007).
Ginkgo biloba Extract (leaf) (std. to 24% ginkgo flavone glycosides & 6% terpene lactones) 100 mg*:
Ginkgo biloba is a widely used herbal supplement with cognitive-enhancing properties. It has been shown to improve memory, cognitive function, and cerebral blood flow (Kaschel, 2011; DeKosky et al., 2008).
F. Lion's Mane Extract (Hericium erinaceus) (fruiting body) (std. to 30% polysaccharides) 400 mg. Lion's Mane is a medicinal mushroom known for its neuroprotective and cognitive-enhancing effects. Studies have shown that it can stimulate nerve growth factor production, improve cognitive function, and protect against neurodegenerative diseases (Mori et al., 2009; Nagano et al., 2010).
Panax ginseng Extract (root) 200 mg. Panax ginseng is a well-known adaptogenic herb with a long history of use in traditional medicine. It has been shown to improve cognitive function, reduce mental fatigue, and enhance stress resistance (Reay et al., 2010; Kim et al., 2018).

Overall: 3.1 / 5

Responsive Table

Test	Result
Attention	3.1
Cognition	2.9
Memory	2.8
Mood	3.3
Stress	3.0
Brain Health	3.1
Learning	3.0
Overall	3.1 / 5

Pros

Minimal reported side effects.
Suitable for long-term use.
Promotes overall brain health.

Cons

Limited ingredient profile and modest dosages.
May take time to see benefits.
Limited research on long-term benefits.
Requires consistent daily use.

Best Nootropics Guide

Potential Side Effects of Nooceptin

Our extensive 12-month evaluation of Nooceptin shows that its side effects are infrequent and generally mild. The ingredients in Nooceptin are safe and well-tolerated by most individuals. Occasionally, users might experience minor side effects such as gastrointestinal discomfort, headaches, or dizziness, but these are usually temporary and resolve on their own.

Citicoline

Citicoline is widely recognized for its safety and minimal side effects. In rare instances, some people might experience gastrointestinal issues, headaches, insomnia, or mild hypotension (Grieb & Rejdak, 2002; Secades & Lorenzo, 2006).

Rhodiola Rosea

This herb is typically well-tolerated, though some users may encounter mild dizziness, dry mouth, or gastrointestinal discomfort. These effects are usually short-lived and resolve independently (Ishaque et al., 2012; Edwards et al., 2012).

Bacopa Monnieri

While generally safe, Bacopa Monnieri can cause gastrointestinal symptoms in some individuals, including nausea, abdominal cramps, and diarrhea. These symptoms are usually mild and diminish over time (Calabrese et al., 2008; Pase et al., 2012).

L-Theanine

L-Theanine is considered very safe with minimal side effects. Some individuals may experience mild headaches, dizziness, or gastrointestinal discomfort (Kakuda, 2011).

Ginkgo Biloba

Ginkgo Biloba is usually well-tolerated, though it can cause mild gastrointestinal symptoms, headaches, dizziness, or allergic skin reactions in some people. Rare cases of bleeding events have been reported, but a direct link to Ginkgo Biloba is not well-established (Kellermann & Kloft, 2011; Hilton & Stuart, 2013).

Lion's Mane (Hericium erinaceus)

Lion's Mane is generally safe for most people, but a few may experience mild gastrointestinal issues or allergic reactions. These side effects are typically rare and not severe (Mori et al., 2009; Nagano et al., 2010).

Panax Ginseng

Panax Ginseng is usually well-tolerated, but some individuals might experience mild side effects such as headaches, gastrointestinal issues, or insomnia. In rare cases, it can cause fluctuations in blood pressure, allergic reactions, or liver toxicity (Lee & Rhee, 2017; Seely & Dugoua, 2008).

Conclusion

Nooceptin markets itself as a natural, well-balanced nootropic, a closer look reveals several shortcomings that limit its overall effectiveness. Although it includes well-known ingredients like citicoline, Rhodiola Rosea, Bacopa monnieri, L-theanine, Ginkgo biloba, Lion's Mane, and Panax ginseng, simply combining popular compounds doesn't guarantee optimal results. Nooceptin lacks synergy-driven formulation—many of its ingredients overlap in function rather than complementing one another, leading to diminishing returns in cognitive enhancement.

The dosages of these ingredients are in some cases underdosed compared to clinical standards, raising concerns about whether users are receiving a therapeutically effective amount.

The best nootropic supplement we've tested is ThinkEase - it provides a results-driven approach to cognitive enhancement. Its formulation is based on clinically validated dosages and synergistic ingredient pairings designed to support not only focus and memory but also long-term brain health and stress resilience. With transparent labeling, bioavailable ingredients and a track record of positive user experiences, ThinkEase is a more advanced, thoughtfully crafted and reliable supplement for those who are serious about enhancing their mental performance.

Best Nootropics Guide

Overall Verdict

3.1 / 5 Stars

Nooceptin is a mild nootropic with a reasonable ingredient profile.
Nooceptin works moderately well as a cognitive enhancer, but overall uses too few ingredients in low doses.
Overall, it's a safe but there are better options available.
Our Recommendation: our recommnedation is to choose a more comprehensively formulated nootropic supplement. ThinkEase is the best nootropic supplement we've tested. We like that it uses 15 ingredients including Acetyl L-Carnitine and Lion's Mane, and uses clinically proven high doses.

Check ThinkEase Deals

FAQs

Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

ThinkEase is our top recommended nootropic supplement. It performed best during our extensive testing for improving memory, focus, and overall brain performance. For more details, check out our complete guide on the best nootropics. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.

References

Alvarez, X. A., et al. (1997). Citicoline improves memory performance in elderly subjects. Methods and Findings in Experimental and Clinical Pharmacology, 19(3), 201-210.
Calabrese, C., et al. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(6), 707-713.
Darbinyan, V., et al. (2000). Rhodiola rosea in stress-induced fatigue: A double-blind, placebo-controlled study. Phytomedicine, 7(5), 365-371.
DeKosky, S. T., et al. (2008). Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA, 300(19), 2253-2262.
Fioravanti, M., & Buckley, A. E. (2006). Citicoline (Cognizin) in the treatment of cognitive impairment. Clinical Interventions in Aging, 1(3), 247-251.
Kim, H. G., et al. (2018). Effects of Panax ginseng on cognitive performance in healthy young adults: a randomized, double-blind, placebo-controlled trial. Journal of Ginseng Research, 42(1), 50-56.
Kimura, K., et al. (2007). L-Theanine reduces psychological and physiological stress responses. Biological Psychology, 74(1), 39-45.
Kaschel, R. (2011). Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. Phytomedicine, 18(14), 1202-1207.
Mori, K., et al. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
Nagano, M., et al. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231-237.
Nobre, A. C., et al. (2008). L-Theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17(S1), 167-168.
Olsson, E. M., et al. (2009). A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Medica, 75(2), 105-112.
Reay, J. L., et al. (2010). Effects of Panax ginseng, consumed with and without glucose, on blood glucose levels and cognitive performance during sustained 'mentally demanding' tasks. Journal of Psychopharmacology, 24(11), 1505-1517.
Stough, C., et al. (2001). The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology, 156(4), 481-484.
Calabrese, C., et al. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(6), 707-713.
Edwards, D., et al. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms - Results of an open-label study. Phytotherapy Research, 26(8), 1220-1225.
Grieb, P., & Rejdak, R. (2002). Pharmacodynamics of citicoline relevant to the treatment of glaucoma. Journal of Neurological Sciences, 173(1), 107-113.
Hilton, M. P., & Stuart, E. L. (2013). Ginkgo biloba for tinnitus. The Cochrane Database of Systematic Reviews, 2013(3), CD003852.
Ishaque, S., et al. (2012). Rhodiola rosea for physical and mental fatigue: A systematic review. BMC Complementary and Alternative Medicine, 12(1), 70.
Kakuda, T. (2011). Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacological Research, 64(2), 162-168.
Kellermann, A. J., & Kloft, C. (2011). Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy, 31(5), 490-502.
Lee, N. H., & Rhee, Y. H. (2017). Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high-fat diet-induced obese C57BL/6J mice. Food & Chemical Toxicology, 100, 169-176.
Mori, K., et al. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
Nagano, M., et al. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231-237.
Pase, M. P., et al. (2012). The cognitive-enhancing effects of Bacopa monnieri: A systematic review of randomized, controlled human clinical trials. Journal of Alternative and Complementary Medicine, 18(7), 647-652.
Seely, D., & Dugoua, J. J. (2008). Panax ginseng safety: A systematic review of adverse effects and drug interactions. Drug Safety, 31(3), 259-273.
Secades, J. J., & Lorenzo, J. L. (2006). Citicoline: Pharmacological and clinical review, 2006 update. Methods and Findings in Experimental and Clinical Pharmacology, 28(Suppl B), 1-56.
Calabrese, C., et al. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: A randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 14(6), 707-713.
Edwards, D., et al. (2012). Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms - Results of an open-label study. Phytotherapy Research, 26(8), 1220-1225.
Grieb, P., & Rejdak, R. (2002). Pharmacodynamics of citicoline relevant to the treatment of glaucoma. Journal of Neurological Sciences, 173(1), 107-113.
Hilton, M. P., & Stuart, E. L. (2013). Ginkgo biloba for tinnitus. The Cochrane Database of Systematic Reviews, 2013(3), CD003852.
Ishaque, S., et al. (2012). Rhodiola rosea for physical and mental fatigue: A systematic review. BMC Complementary and Alternative Medicine, 12(1), 70.
Kakuda, T. (2011). Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacological Research, 64(2), 162-168.
Kellermann, A. J., & Kloft, C. (2011). Is there a risk of bleeding associated with standardized Ginkgo biloba extract therapy? A systematic review and meta-analysis. Pharmacotherapy, 31(5), 490-502.
Lee, N. H., & Rhee, Y. H. (2017). Korean red ginseng (Panax ginseng) prevents obesity by inhibiting angiogenesis in high-fat diet-induced obese C57BL/6J mice. Food & Chemical Toxicology, 100, 169-176.
Mori, K., et al. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double-blind placebo-controlled clinical trial. Phytotherapy Research, 23(3), 367-372.
Nagano, M., et al. (2010). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231-237.
Pase, M. P., et al. (2012). The cognitive-enhancing effects of Bacopa monnieri: A systematic review of randomized, controlled human clinical trials. Journal of Alternative and Complementary Medicine, 18(7), 647-652.
Secades, J. J., & Lorenzo, J. L. (2006). Citicoline: Pharmacological and clinical review, 2006 update. Methods and Findings in Experimental and Clinical Pharmacology, 28(Suppl B), 1-56.