Best Nootropics Guide - The 10 Best Nootropics 2023

Best Nootropics - Top 10

June 8, 2023

In the hustle and bustle of our fast-paced world, it's easy to feel overwhelmed and lose focus. But here's the good news: nootropics, often referred to as 'smart drugs', are here to save the day. The best nootropic supplements are gaining traction for a compelling reason—they help you stay alert, mentally clear, and full of vigor even when life is at its most demanding.

With the rise in popularity of nootropics over the past few years, the market is now brimming with options. Finding the best nootropic for your needs can feel like searching for a needle in a haystack. That's where we come in. We've combed through the science, dissected the data, and reviewed the best nootropics available. So, sit back and relax—let DBEM's guide to the best nootropics 2023 help you navigate the world of nootropics. We'll help you find on the best brain supplement for your needs.

Overall Verdict

NooCube Best Nootropic



4.9 / 5 Stars

  • Improves Focus, Cognitive Processing, Mood and Energy
  • Comprehensive Ingredient Profile
  • Clinically Proven
Nooceptin Best Nootropic For Learning



4.8 / 5 Stars

  • Supports Cognitive Function
  • Improves Memory Retention and Recall
  • Improves Overall Brain Function



4.8 / 5 Stars

  • Exceptional For Performing Under Pressure
  • Improves Focus and Concentration
  • High Doses of Proven Ingredients

1. NooCube - Best Nootropic Overall

A comprehensive and clinically proven ingredient profile makes NooCube DBEM's best nootropic overall.

NooCube has been found to enhance cognitive function, promote mental clarity and focus, and increase energy levels. Additionally, it may improve productivity and create a more positive outlook on life.

Individuals who take NooCube have reported better thought control, increased ability to maintain individual thought strands, and improved focus on tasks. Reaction times may also improve, which is particularly beneficial for athletes or anyone engaged in sports or other activities that require quick reflexes. Memory, spatial awareness, and mindfulness may also be enhanced by NooCube, leading to greater productivity and overall happiness.

NooCube Best Nootropic


  • Cost effective
  • Rounded ingredient profile covers most bases
  • Inclusion of Lutemax 2020 is unique
  • Money back guarantee


  • Great all rounder but doesn't excel across every single area
  • Single unit purchase is expensive

NooCube Ingredients (click to reveal)

  • LuteMax 2020
  • Bacopa Monnieri (250mg)
  • Huperzine A (20mg)
  • Pterostilbene (140mcg)
  • Resveratrol (14.3mg)
  • L-theanine (100mg)
  • L-tyrosine (250mg)
  • Alpha GPC (50mg)
  • Oat straw
  • Cat’s claw
  • Vitamin B1 (1.1mg)
  • Vitamin B7 (50mcg)
  • Vitamin B12 (2.5mcg)

One of the key features of NooCube is its all-natural, non-toxic, and side effect-free formula. The product contains 13 ingredients that are well-known in the nootropic world for their effectiveness. Bacopa Monnieri, for example, is an herb that enhances the reception of nerve signals, leading to improved reaction times and enhanced cognition.

Alpha GPC is another ingredient found in NooCube that enhances the body's production of acetylcholine, a neurotransmitter that plays a crucial role in memory and learning. L-theanine and L-tyrosine are two more components that elevate mood, improve attention span and reaction times, and diminish stress levels and fatigue symptoms.

NooCube also includes Huperzine A to enhance memory function and oat straw extract to improve responsiveness. Both of these ingredients also aid in focus and concentration. The polyphenols Resveratrol and pterostilbene, commonly found in berries, are excellent antioxidants that slow the aging process and help to prevent age-related cognitive decline.

All of these ingredients work together to keep the brain healthy and fully functioning. NooCube improves cognition and focus, boosts energy levels, and fights aging, leading to a happier, clearer-headed, and more efficient you. The latest update to the formulation now includes Lutemax 2020 which is proven to support attention, verbal memory, processing speed and stress response.


We've tried and tested NooCube with great success, and highly recommend it to anyone looking to improve their cognitive function and overall well-being.

When purchasing NooCube from the official website, customers receive a 60-day money-back guarantee. This is a fantastic deal for a fantastic product - one of the most potent and effective nootropics available on the market today. 

2. Nooceptin - Best For Cognition And Learning

Nooceptin, a stellar nootropic blend by SAP Nutra, has been turning heads for its remarkable potential in enhancing cognitive function and overall brain health.

Nooceptin lives up to its claims of being a potent cognitive enhancer. It enhances memory retention and recall, sharpens focus, reduces stress and anxiety, stimulates the growth of new brain cells, and fortifies neuron connections. It helps you realize your complete cognitive potential and may even have a positive impact on Alzheimer's Disease.

Nooceptin optimizes brain performance via six principal mechanisms. It enhances cerebral blood flow, ensuring brain cells receive ample oxygen and nutrients, leading to clear thinking. It stimulates dendrite growth on neurons, thus reinforcing neuron connections and enhancing brainpower. Nooceptin promotes brain cell development by increasing neurotrophic factors, responsible for new brain cell formation and maturity. It surges the levels of Acetylcholine, a neurotransmitter vital for focus, learning, and information processing. Furthermore, Nooceptin aids in superior memory retention and swift recall, and acts as a brain shield, protecting against the detrimental effects of stress and anxiety.

Nooceptin Best Nootropic For Cognitive Performance And Brain Health Review


  • Natural ingredients proven to work.
  • Ingredients work in synergy.
  • Suitable for long-term use.
  • Supports all areas of cognition and mental performance.
  • Promotes overall brain health.


  • May take a few weeks to experience results.
  • Requires consistent daily use for best results.

Nooceptin Ingredients (click to reveal)

  • Lion’s Mane (400 mg)
  • Citicoline (200 mg)
  • Rhodiola Rosea (150 mg)
  • L-Theanine (200 mg)
  • Bacopa Monnieri Extract (150 mg)
  • Ginkgo Biloba Extract (100 mg)
  • Panax Ginseng (200 mg)

Nooceptin's clear and well-dosed ingredient profile is impressive. Nooceptin's formula is a blend of natural ingredients known for cognitive benefits like Citicoline, Rhodiola Rosea, Bacopa monnieri, L-Theanine, Ginkgo biloba, Lion's Mane, and Panax ginseng.

Citicoline is a naturally occurring compound vital for the synthesis of phosphatidylcholine, a crucial component of cell membranes. Rhodiola Rosea is an adaptogenic herb that enhances cognitive function, reduces mental fatigue, and improves stress resistance. Bacopa monnieri, a traditional Ayurvedic herb, is known for its cognitive-enhancing properties. L-Theanine, an amino acid found primarily in green tea, promotes relaxation, reduces stress, and improves focus and attention. Ginkgo biloba, a widely used herbal supplement, improves memory, cognitive function, and cerebral blood flow. Lion's Mane, a medicinal mushroom, stimulates nerve growth factor production, improves cognitive function, and protects against neurodegenerative diseases. Panax ginseng is a well-known adaptogenic herb, it improves cognitive function, reduces mental fatigue, and enhances stress resistance.


Nooceptin presents a compelling case as a cognitive enhancer, especially for professionals in high-pressure environments. By enhancing focus and decreasing stress, Nooceptin could contribute to improved productivity, and alleviate feelings of stress or anxiety during high-pressure moments. Its potent blend of natural ingredients, coupled with its scientifically-proven benefits, make it an excellent choice for those seeking to boost their cognitive abilities, whilst also supporting long-term brain health.

3. Vyvamind - Best For Focused Performance

A single-minded focus on performance makes Vyvamind the best nootropic for high performers and people working under pressure.

VyvaMind is undoubtedly one of the best nootropic supplements available in the market. Its all-natural formula has undergone years of refinement to achieve the fantastic version 4.2.1 that we have today. This brain booster is ideal for those who want to take their cognitive performance to the next level and reach their full potential.

Although VyvaMind only contains six ingredients, it is a powerhouse that effectively enhances focus, concentration, memory, motivation, mood, stress, anxiety, and energy levels.

Vyvamind Best Nootropic For Focus


  • Focused on performance above all else
  • All ingredients at clinically proven levels
  • Supports fast processing of information


  • Not designed to enhance memory, or help with stress or anxiety
  • Only available in USA

Vyvamind Ingredients (click to reveal)

  • L-Tyrosine (300 mg)
  • Citicoline (200 mg)
  • L-Theanine (150 mg)
  • Caffeine (75 mg)
  • Vitamin B6 (2.5 mg)
  • Vitamin B12 (50 mcg)

VyvaMind's ingredient list is seriously impressive, featuring standout components such as Citicoline, which is not commonly found in other nootropic supplements. This natural compound provides long-lasting energy levels that can significantly boost your focus and concentration. Moreover, it is believed to have significant benefits for long-term brain health.

With only 75mg of caffeine per serving, it's unlikely to leave you feeling jittery or anxious like some other brands. The addition of B vitamins is also a clever move that can improve memory, mood, and overall brain health.

L-Theanine and L-Tyrosine are also key ingredients in VyvaMind that have numerous benefits, including improved attention span, creativity, and a sense of calm focus.


VyvaMind is a top-tier nootropic supplement that is affordable and effective. It is perfect for anyone looking to elevate their cognitive abilities and achieve their full potential.

4. ProMind Complex - Best For Memory

Created by Carl Henderson, this product has shown remarkable results in improving both short-term and long-term memory.

ProMind Complex is a powerful, all-natural supplement formulated to enhance cerebral health, increase memory retention, and elevate cognitive performance.

Designed to cater to individuals dealing with memory lapses, brain fog, and memory retention issues, ProMind Complex brings a new lease on cognitive life, especially to those who are battling age-related cognitive decline or neuronal dysfunction. It is a beacon of hope for those who want to regain their mental agility and say goodbye to distressing "senior moments."

ProMind Complex uses ingredients known for their efficacy in promoting brain health and enhancing memory function. These benefits include reducing cell death, lowering the risk of neurodegenerative disorders like Alzheimer's, and boosting the release of neurotransmitters responsible for memory and recall.

ProMind Complex is also unique in working to balance beneficial and harmful bacteria in the brain, which is crucial for optimal brain health.

Best Nootropic For Memory ProMind Complex


  • Designed for seniors
  • Provides memory support
  • Ingredient profile boosts brain health
  • Aids cognitive function
  • 60 day money back guarantee


  • Not for everyone, ProMind is formulated for the needs of seniors and people needing memory support
  • Only available direct from ProMind

ProMind Complex Ingredients (click to reveal)

  • St. John's Wort (250mg)
  • L-Glutamine (150mg)
  • Phosphatidylserine (125mg)
  • Bacopa Monnieri (120mg)
  • Ginkgo Biloba (50mg)
  • N-Acetyl L-Carnitine (50mg)
  • Vinpocetine (2mg)
  • Huperzine-A (10mcg)

Ingredients in ProMind Complex include L-Glutamine, Bacopa Monnieri Extract, Ginkgo Biloba, N-Acetyl L-Carnitine Hydrochloride, Vinpocetine, and Huperzine. Each of these ingredients plays a significant role in how the product works.

L-Glutamine enhances neural communication, reduces anxiety, and maintains brain function by lowering cortisol levels. Bacopa Monnieri Extract is clinically proven to boost memory, support memory retention, and help foster clear thinking. Ginkgo Biloba, combats free radicals, decreases brain damage, and enhances cerebral blood flow.

N-Acetyl L-Carnitine Hydrochloride is vital for a healthy brain, reducing inflammation and optimizing energy production. Vinpocetine increases brain blood flow, facilitates oxygen and glucose uptake, and enhances cerebral metabolism. Lastly, Huperzine serves as a neuroprotective agent, dispelling brain fog, increasing alertness, and fostering clear thinking.


ProMind Complex is the most effective product we've analyzed and tested as a memory enhancing nootropic. It's effective in boosting cerebral blood flow and slowing neurodegeneration. It also shows significant promise in its ability to guard against degenerative brain diseases like Alzheimer's and in sharpening memory. The supplement is effective in reducing the frequency of 'senior moments' by supporting clear thinking. With ProMind Complex, enhanced memory retention is no longer out of reach.

5. Mind Lab Pro

Mind Lab Pro by Opti-Nutra is a top-tier nootropic supplement that offers multi-pathway cognitive support.

Mind Lab's comprehensive formula combines several key ingredients to promote optimized brain regeneration and protection, as well as healthy neurotransmitter levels. Unlike many other nootropics that focus on only one or two cognitive aspects, Mind Lab Pro offers a "whole brain" solution.

Thanks to its scientifically-backed formula, Mind Lab Pro is one of the best-researched and most data-driven nootropic supplements on the market. Its powerful blend of natural ingredients has been carefully selected to enhance both short-term and long-term cognitive health.

So what can you expect from using Mind Lab Pro? For starters, the supplement aims to boost your memory and information recall, making it easier and faster to process and retain new information. It also promotes greater focus, clarity, and multitasking ability, helping you stay on top of your game. Mind Lab Pro also provides a clean and natural energy boost, without the use of stimulants. Its blend of natural ingredients helps improve energy, motivation, and mood, while keeping you calm and level-headed.

Mind Lab Pro Best Nootropics Review


  • Comprehensive formula supports all areas of cognitive performance.
  • High-quality, safe and clinically-backed ingredients.
  • Suitable for vegans and free from allergens.
  • Absence of stimulants reduces potential side effects.
  • Enhanced bioavailability through NutriGenesis® vitamins.
  • Transparent labeling and dosages.


  • May be expensive for some users.
  • No caffeine.
  • Only available from Mind Lab.

Mind Lab Pro Ingredients (click to reveal)

  • Lion’s mane mushroom (500 mg)
  • Citicoline (250 mg)
  • L-tyrosine (175 mg)
  • Brahmi herb (150 mg)
  • L-theanine (100 mg)
  • Phosphatidylserine (100 mg)
  • Maritime or cluster pine (75 mg)
  • Rhodiola rosea (50 mg)
  • Vitamin B6 (2.5 mg)
  • Vitamin B9 (100 mcg)
  • Vitamin B12 (7.5 mcg)

Mind Lab Pro can help support neural plasticity and combat the natural cognitive decline that comes with aging. Its intelligent blend of 11 natural nootropics includes lion's mane, which promotes optimal NGF production for neural regeneration and maintenance, as well as citicoline, PS, bacopa monnieri, and maritime pine bark, all of which help slow cognitive decline, improve mental clarity, and enhance memory and learning.

The formula also includes both l-tyrosine and l-theanine, which work together to optimize mental performance, reduce the effects of stress and fatigue, and promote greater attention, focus and clarity.

Mind Lab Pro's solid vitamin B complex (including vitamins B6, B9, and B12) works together to improve mental performance, balance your mood, and promote long-term cognitive health, especially against age-related cognitive decline.


One standout feature of Mind Lab Pro is its inclusion of rhodiola rosea, a well-known herbal adaptogen. Rhodiola rosea helps maintain high levels of cognitive energy, reduces the effects of mental and physical stress, and enhances attention span, mental processing, and work capacity. With rhodiola rosea, Mind Lab Pro delivers clarity while keeping you calm and in a positive mood.

6. Kaged Mindset - Best Nootropic Drink

Kaged Mindset has entered the world of nootropics with an innovative product format, the nootropic drink.

Developed by Kaged, an elite supplement brand, Mindset stands out with its unique delivery format - a powder that mixes into a refreshing orange mango-flavored drink, offering a welcome alternative to conventional nootropic capsules.

Kaged Mindset promises to skyrocket productivity, enhance attention, sustain focus, and sharpen working memory. These claims, coupled with the fact that it's stimulant-free and devoid of banned substances, make it an appealing option, especially for athletes.

Best Nootropic Drink


  • Innovative drinkable nootropic
  • Improves focus and cognitive performance
  • Scientifically-backed ingredients
  • Boosts energy without jitters
  • Caffeinated and non-caffeinated versions available
  • Orange mango flavor tastes good
  • GMO-free and plant-based


  • Requires mixing 
  • Limited flavor options

Kaged Mindset Ingredients (click to reveal)

  • AlphaSize Alpha GPC (1200mg)
  • Cereboost® American Ginseng Extract (200mg)
  • SunPS® Phosphatidylserine (100mg)
  • Huperzine A (10mg)
  • L-Tyrosine (1000mg)
  • Ioniplex® Mineral Complex (100mg)
  • Acetyl-L-Carnitine (1000mg)
  • L-Phenylalanine (300mg)
  • Vitamin C (150mg)
  • B Vitamin Complex

The product's formulation is backed by scientific research, featuring carefully selected ingredients known for their cognitive-enhancing properties. AlphaSize Alpha GPC, Cereboost® American Ginseng Extract, SunPS® Phosphatidylserine, and Huperzine A are among the key ingredients that aim to improve cognitive function, memory, and learning. Other constituents such as L-Tyrosine, Ioniplex® Mineral Complex, Acetyl-L-Carnitine, and L-Phenylalanine are linked to improved cognitive performance, energy metabolism, and overall health. The inclusion of PureWayC® Vitamin C and a B Vitamin Complex further underscores Kaged's commitment to comprehensive health benefits.

In a DBEM study involving athletes, Kaged Mindset exhibited almost immediate impact, a stark contrast to other nootropics that often take days or sometimes weeks to yield perceivable improvements in cognitive performance. The non-caffeinated version provided an initial boost in focus and energy, lasting approximately 1.5 to 2 hours, while the caffeinated version extended these effects to 3-4 hours. It tastes great, is easy to mix and is great on-the-go.


Kaged Mindset has made a strong entry into the nootropic market. It delivers on its claims of enhanced attention, focus, and productivity while offering a refreshing, easy-to-consume alternative to traditional nootropic capsules. The product's science-backed formulation, coupled with the immediate effects observed in the study, positions it as a promising contender in the realm of cognitive-enhancing supplements. While the memory improvement was not immediately evident, it could also yield long-term improvements in this area given the presence of ingredients known to enhance memory function.

7. Performance Lab Mind

Performance Lab Mind is an innovative nootropic that claims to not only enhance cognition but also aid in brain recovery from intense mental exertion.

Unlike many other nootropics, Performance Lab Mind aims to boost numerous performance-driven cognitive functions, including focus, speed, energy, memory, and motivation. It's also designed to combat stress burnout, promoting faster recovery and supporting long-term brain health.

The product works by encouraging blood flow to the brain, and promoting a flexible and healthy neural structure linked to memory and learning. The product also aims to restore brain chemicals, enhancing sharper bounce back from mental exertion while providing stim-free mental energy.

Best Nootropic


  • Very high quality ingredients
  • All ingredients at clinically proven levels
  • Supports mental recovery


  • Ingredient profile is very focused, may not yield comparable results for everyone 
  • Long-term brain benefits difficult to perceive and measure

Performance Lab Mind Ingredients (click to reveal)

  • Citicoline (250mg)
  • Phosphatidylserine (100mg)
  • L-Tyrosine (250mg)
  • Maritime Pine Bark Extract (75mg)

The key ingredients include Cognizin® Citicoline, Sharp-PS® Green (Soy-Free) Phosphatidylserine, Ajipure® L-Tyrosine, and Maritime Pine Bark Extract. Citicoline, a versatile nootropic, aids in building and optimizing brain cell functions, raising acetylcholine to support learning, attention, and memory, and stabilizing brain cell membranes for healthy neural repair and function. Phosphatidylserine aids in the efficient function and long-range health of brain cell membranes, while L-Tyrosine and Maritime Pine Bark Extract contribute to brain health and mental clarity.


Performance Lab Mind stands out as a unique nootropic. It not only enhances cognitive functions but also supports the brain's recovery from mental exertion. Its blend of scientifically-backed ingredients and stim-free formula making it a suitable choice for a wide range of people. With consistent use, Performance Lab Mind is well formulated to support long-term brain health as well as providing more immediate improvements in cognition.

8. Thesis Nootropics

Thesis Nootropics offers a novel approach in the cognitive enhancement supplement space by prioritizing personalization.

Each user receives a tailored solution, designed to cater to their unique cognitive needs and preferences, setting Thesis Nootropics apart from most competitors. Backed by extensive experience and a vast database of nootropic research, they leverage scientific and data-driven methods to refine their formulas.

The personalization process is user-friendly, requiring no lab tests or detailed medical history. Customers fill out an online questionnaire, and based on this, they receive a tailored set of nootropic blends to sample before settling on a specific formula. The company also assigns a personal nootropics expert to each customer, serving as a guide to navigate and optimize the nootropic regimen. While the premium pricing may deter some potential customers, the extra cost supports this high level of personalized service and product customization.

Thesis Best Nootropics


  • Multiple blend options results in a more targeted ingredient profile for individual needs
  • Good customer service and attention to detail


  • Very expensive compared to other options
  • Personalization is more limited than it appears, buying are sold one of 6 pre-made blends
  • Each Thesis blend offers a more narrow range of benefits than most competitor products
  • Questionnaire takes some time to complete

Thesis Nootropics Ingredients (click to reveal)

  • Lion’s Mane
  • Epicatechin
  • L-Theanine
  • Forskolin
  • Magnolia Bark Extract
  • Sage Extract
  • Choline
  • TeaCrine
  • Triacetyluridine
  • Theobromine
  • Panax Ginseng
  • Ashwagandha

The company's nootropic blends cater to a variety of cognitive functions, including increased cognitive energy, enhanced mental clarity, improved memory and learning abilities, reduced brain fog, elevated mood, and stress reduction. The standout feature is the personalization, which allows users to optimize their cognitive enhancement based on individual needs.

While Thesis has not conducted independent research on their nootropic blends, they do cite scientific papers in support of several ingredients used. These include Teacrine, Dynamine, Zembrin, Synapsa, Ashwagandha, and Alpha GPC. However, it's important to note that comprehensive evidence is lacking for many of the 30+ ingredients used across their range.

The company offers various blends, each targeting different cognitive aspects. These include the Energy blend (containing choline, NAC, NALT, Sabroxy®, TeaCrine®, Zynamite®, caffeine, and L-theanine), the Clarity blend (7,8-DHF, Alpha GPC, Epicatechin, Lion's Mane, caffeine, and L-theanine), and the Motivation blend (Artichoke extract, Dynamine®, Forskolin, L-phenylalanine, vitamin B12, caffeine, and L-theanine).


Thesis Nootropics offers a comprehensive, personalized cognitive enhancement solution. The higher price point may deter some, but the tailored approach and expert guidance could justify the additional cost for those seeking an advanced and individualized cognitive enhancement solution. While some ingredients lack comprehensive scientific evidence, the use of recognized nootropic components and personalized guidance may make this a suitable option for those looking to optimize cognitive function.

9. Centrapeak

Centrapeak is a unique nootropic that aims to uplift your mood and improve cognitive function whilst also supporting testosterone levels. 

Centrapeak's formulation has two distinct components, nootropic ingredients to promote mental wellness and ingredients known to support healthy testosterone levels. Interestingly, healthy testosterone levels also support mental well-being, meaning Centrapeak can be considered a well-rounded nootropic for men, particularly those over 35 years old.

Proven nootropic ingredients, such as rhodiola rosea and phosphatidylserine improve mental clarity and promote feelings of well-being. Whilst ingredients including vitamin D, boron and zinc work to help support testosterone levels.

Centrapeak best nootropic


  • Supports cognitive health and performance
  • Unique in working to support cognitive performance by also supporting testosterone levels


  • Fewer dedicated nootropic ingredients than other brands

Centrapeak Ingredients (click to reveal)

  • Vitamin D3 (82.5mcg)
  • Zinc (20mg)
  • B6 (10mg)
  • Boron (10mg)
  • Phosphatidylserine (100mg)
  • K2 (45mcg)
  • Indole-3-Carbinol (200mg)
  • Ashwagandha (200mg)
  • Mucuna Pruriens (75mg)
  • Rhodiola rosea (100mg)
  • Pine Bark Extract (75mg)
  • L-Tyrosine (150mg)

Key ingredients include citicoline, phosphatidylserine, l-tyrosine, and maritime pine bark extract. Citicoline, a versatile nootropic, aids in building and optimizing brain cell functions, raising acetylcholine to support learning, attention, and memory, and stabilizing brain cell membranes for healthy neural repair and function. Phosphatidylserine aids in the efficient function and long-range health of brain cell membranes, while l-tyrosine and maritime pine bark extract contribute to brain health and mental clarity.


Centrapeak is a comprehensive supplement that targets both physical and mental wellbeing. It combines a range of vitamins, minerals, and botanicals known for their potential benefits in mood enhancement, cognitive function, and hormone balance. The inclusion of ingredients typically found in nootropics sets it apart from conventional testosterone boosters. Therefore, if you're seeking a supplement that goes beyond boosting testosterone and delves into the realm of cognitive enhancement and mood improvement, Centrapeak is worth considering.

10. Onnit Alpha Brain

The combination of misleading claims and the use of opaque proprietary blends means Alpha Brain isn't one of our top rated nootropics, but it isn't terrible either. 

Alpha Brain from Onnit has had a lot of high profile publicity, due to its link with Joe Rogan. For those that don't know, Joe Rogan is a well-known comedian, podcaster, and mixed martial arts commentator who has long been associated with Onnit, the company behind Alpha Brain. Rogan has been an outspoken advocate for Onnit's products and has helped to spread the word about their cognitive-boosting benefits.

However, Rogan has made many unsupported claims about the effectiveness of Alpha Brain and other Onnit supplements. Despite this, Alpha Brain remains a popular nootropic supplement that is believed to enhance cognitive function by many. But it's fair to say there are many better formulated products with proper scientific backing than Alpha Brain.

Alpha Brain Best Nootropics


  • Some good ingredients known for nootropic benefits
  • Inclusion of phosphatidylserine, recognized by FDA as effective at boosting cognition


  • Unproven claims
  • Inclusion of ingredients not recognized for their claimed effects on cognitive performance
  • Many ingredients under dosed
  • Ingredients hidden in proprietary blends

Alpha Brain Ingredients (click to reveal)

  • Vitamin B6 (Pyridoxine HCl)
  • Onnit Flow Blend (650 mg): This proprietary blend consists of Bacopa Monniera Extract, Cat's Claw Extract (AC-11), Huperzia Serrata Extract, and Oat Straw Extract.
  • Onnit Focus Blend (240 mg): This blend includes Alpha GPC, Bacopa Monniera, and Huperzia Serrata
  • Onnit Fuel Blend (65 mg): This blend comprises L-Leucine, Vinpocetine, and Pterostilbene
  • L-Tyrosine
  • L-Theanine
  • Phosphatidylserine
  • Alpha GPC
  • Bacopa Monniera
  • Huperzia Serrata
  • Oat Straw Extract
  • Vinpocetine
  • Pterostilbene

Alpha brain uses proprietary blends, which essential mask the levels of ingredients used, making it impossible to know which ingredients are clinically dosed and which are there purely for marketing reasons. It's accurate to say that it's not possible for all the ingredients in Alpha Brain to be at clinically proven levels as the amounts of each proprietary blend used is declared.

Alpha Brain's ingredients include l-tyrosine and l-theanine, which help to raise levels of serotonin and dopamine in the body, thus improving cognitive abilities and cutting through brain fog and fatigue. Another important ingredient is oat straw extract, which improves blood flow to the brain and enhances oxygen and glucose delivery to keep the brain sharp and highly energized.

Alpha Brain also focuses on increasing the body's natural production of acetylcholine, an essential neurotransmitter involved in communication within the brain and between the brain and the rest of the body. This is achieved through a combination of Alpha GPC, bacopa, and phosphatidylserine, the latter of which is the only nootropic recognized by the FDA for boosting cognitive function.

Alpha Brain also contains huperzia serrata, which inhibits the production of the catalyst acetylcholinesterase to maintain higher levels of acetylcholine in the body. However, it's worth noting that some of the claims made by Alpha Brain may lack scientific merit, and the other ingredients may not offer any significant cognitive benefits.


Alpha Brain is a nootropic supplement that aims to improve cognitive function through a unique blend of proprietary supplements and natural ingredients. These supplements work together to optimize serotonin and dopamine response, increase levels of acetylcholine, and aid cellular communication, ultimately resulting in improved mood, energy levels, and faster, more focused thinking.

Some of the claims made by Joe Rogan and Onnit are baseless and some ingredients are proved at dosages too low to be effective. However, it's not a terrible product and some people will experience some cognitive benefits.

Best Overall

If you're interested in nootropics that support improved cognitive function, including memory, focus, and mental clarity, the best overall nootropic in our view is NooCube.

NooCube vs Vyvamind


4.9 / 5

Noocube is formulated to improve multiple aspects of cognitive function, including memory, focus, and mental clarity. It contains a wider range of ingredients than almost any other product, including Alpha GPC, Huperzine A, and Bacopa Monnieri, which have been extensively studied and shown to have significant cognitive benefits. 

Overall, Noocube is our go-to all round top performing nootropic due to its well rounded ingredient profile and wide ranging performance and brain health benefits.


Vyvamind is a nootropic supplement that contains six key ingredients that have been selected for their cognitive enhancing properties. Vyvamind is a very good option for people needing a performance-focused nootropic supplement, particularly those in mentally demanding situations and those needing to perform under pressure.

However, for those looking to improve multiple aspects of their cognitive performance and brain health, NooCube may be a better alternative. NooCube contains a unique blend of clinically studied ingredients that have been shown to enhance memory, focus, and overall brain function [32,33]. NooCube also includes ingredients such as Bacopa monnieri, Huperzine A, and Oat Straw that have been shown to improve brain health and reduce the risk of age-related cognitive decline [34,35].

NooCube Best Nootropic



4.9 / 5 Stars

  • Improves Focus, Cognitive Processing, Mood and Energy
  • Comprehensive Ingredient Profile
  • Clinically Proven
Nooceptin Best Nootropic For Learning



4.8 / 5 Stars

  • Supports Cognitive Function
  • Improves Memory Retention and Recall
  • Improves Overall Brain Function



4.8 / 5 Stars

  • Exceptional For Performing Under Pressure
  • Improves Focus and Concentration
  • High Doses of Proven Ingredients


Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

Popular nootropic supplements include NooCube, Mind Lab Pro, and Vyvamind. NooCube contains a blend of ingredients that may improve memory, focus, and overall cognitive function. Mind Lab Pro is designed to support brain health and cognitive performance through a variety of ingredients, including vitamins, minerals, and plant-based compounds. Vyvamind is a premium nootropic supplement that focuses almost exlcusively on cognitive function and mental performance. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.


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  4. L-Tyrosine: Jongkees BJ, Hommel B, Kühn S, Colzato LS. Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of Psychiatric Research. 2015. (
  5. Rhodiola Rosea: Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000. (
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  11. N-Acetyl L-Carnitine Hydrochloride: Malaguarnera M, Cammalleri L, Gargante MP, Vacante M, Colonna V, Motta M. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007. (
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  13. Huperzine: Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci. 2006. (
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  17. Indole-3-Carbinol: Beecher CWW. Cancer preventive properties of varieties of Brassica oleracea: a review. Am J Clin Nutr. 1994. (
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  19. Pine Bark Extract: Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey L, Kure C, Lloyd J, Stough C. An examination of the effects of the antioxidant Pycnogenol on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population. J Psychopharmacol. 2008. (
  20. Korean Panax Ginseng: Reay JL, Scholey AB, Kennedy DO. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol. 2005. (
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  23. BioPerine® (Piperine): Khajuria A, Zutshi U, Bedi KL. Permeability characteristics of piperine on oral absorption--an active alkaloid from peppers and a bioavailability enhancer. Indian J Exp Biol. 1998. (