Nooceptin vs Alpha Brain: A Comprehensive Comparison

July 19, 2023

Nootropics are gaining popularity as people look for ways to enhance their cognitive functions, motivation, and memory. Nooceptin and Alpha Brain are two prominent nootropic supplements available in the market. While both claim to offer remarkable benefits, a deeper analysis of their ingredients, effectiveness, and safety is necessary to understand which one is a better choice overall.

Nooceptin is a top-rated nootropic known for its potent blend of ingredients that work synergistically to enhance cognitive function, whereas Alpha Brain is a well-known product backed by celebrity endorsements. When comparing these two nootropic supplements, it’s essential to consider not just their effectiveness, but also potential side effects, pricing, and overall value.

Nooceptin Best Nootropic For Learning

Overall Verdict

 4.8 / 5 Stars

  • Nooceptin and Alpha Brain are both nootropic supplements designed to support cognitive function. The main difference between the two lies in their ingredient composition. While Alpha Brain contains several well-known ingredients like Alpha-GPC and Huperzine-A, Nooceptin reportedly has a slightly different formula, which some users have found to be more effective for cognitive enhancement.
  • Nooceptin has fewer potential side effects than Alpha Brain.
  • Our firsthand experience consistently found Nooceptin was more effective for both short-term and long-term brain function. 

Nooceptin Vs Alpha Brain

History and Background

Nooceptin and Alpha Brain are both popular nootropic supplements designed to enhance cognitive function, memory, and focus. Nooceptin has been praised for being highly effective with minimal side effects, while Alpha Brain is more well-known due to the endorsement of Joe Rogan and the company Onnit that produces it.

Both supplements aim to improve brain function by promoting the production and effectiveness of neurotransmitters, particularly acetylcholine. Acetylcholine plays a crucial role in learning, memory, and overall cognitive function.

Key Differences

Several key differences set Nooceptin and Alpha Brain apart:

  • Ingredients: Despite having similar goals, the two nootropic supplements have different ingredient profiles. Nooceptin contains a blend of ingredients designed for rapid results while also protecting long-term brain health. Alpha Brain, on the other hand, uses a unique blend focused on short-term results with unclear long-term benefits.
  • Efficacy: Users report that Nooceptin is more effective than Alpha Brain. The carefully chosen ingredients in Nooceptin work together to create noticeable improvements in cognitive function, while the effects of Alpha Brain tend to wear off after an hour or so.
  • Side Effects: Nooceptin has a reputation for being well-tolerated, with minimal side effects. Alpha Brain, however, has a history of causing some mild side effects, although the extent to which they impact users varies.
  • Natural vs. Synthetic: Nooceptin emphasizes the use of natural ingredients to support brain function and neurotransmitter production. In contrast, Alpha Brain’s ingredient list contains a mix of natural and synthetic components, which may be less appealing to those seeking a more natural approach.
  • Choline Sources: Both nootropic supplements contain choline, a vital nutrient for brain health and acetylcholine production. However, the source of choline differs between the two. Nooceptin utilizes natural choline sources, while Alpha Brain includes synthetic forms of choline. Natural choline sources are generally considered more effective and better absorbed by the body.

While both Nooceptin and Alpha Brain aim to improve cognitive function and support brain health, they differ in ingredients, effectiveness, side effects, and their approach to using natural or synthetic components. Users looking for a nootropic supplement should carefully consider these differences to make an informed decision on which option may be best suited for their needs.

Ingredients Comparison

Nooceptin Formula

Nooceptin is a nootropic supplement designed to promote cognitive enhancement through a carefully crafted formula. The ingredients in Nooceptin focus on improving various aspects of mental faculties, such as attention, recall, and concentration. Some of the key ingredients found in Nooceptin include:

  • Bacopa Monnieri: Known for its ability to reduce stress and anxiety, Bacopa Monnieri is a popular choice in nootropics. It helps to improve memory and cognitive function by influencing neurotransmitters in the brain.
  • Citicoline: This compound is crucial for the production of neurotransmitters and overall brain health. Citicoline helps enhance concentration, attention, and overall cognitive function.
  • Ginkgo Biloba: This ancient herb is known to improve blood flow to the brain and provide antioxidant protection. In turn, Ginkgo Biloba is believed to enhance cognitive function, particularly in aspects like attention and memory.

Alpha Brain Formula

Alpha Brain is another popular nootropic supplement that claims to improve cognitive function and provide various cognitive enhancement benefits. The ingredients in Alpha Brain are designed to target neurotransmitters, boost mental capacity, and improve overall brain health. Some prominent ingredients in Alpha Brain’s formula include:

  • Bacopa Monnieri: Similar to Nooceptin, Alpha Brain also contains Bacopa Monnieri, known for its anxiety and stress-relieving properties and ability to support memory enhancement.
  • Huperzine A: This compound is known to inhibit an enzyme that degrades the neurotransmitter acetylcholine, resulting in improved cognitive function and memory.
  • Vinpocetine: This synthetic compound is included in Alpha Brain to improve blood flow to the brain, which is believed to benefit cognitive function and overall brain health.

In summary, both Nooceptin and Alpha Brain formulas contain ingredients to promote cognitive enhancement and address different aspects of mental faculties, such as attention, recall, and concentration. While there is some overlap of ingredients, such as Bacopa Monnieri, there are also unique components in each formula that cater to specific cognitive needs.

Benefits and Efficacy

Cognitive Performance

Nooceptin and Alpha Brain are both marketed as cognitive enhancers designed to support mental performance and improve cognitive abilities. Nooceptin is known for its synergistic blend of ingredients, including L-theanine, Alpha GPC, and Rhodiola Rosea, which can help combat brain fog and boost energy levels throughout the day.

On the other hand, Alpha Brain also contains a unique blend of ingredients, including L-theanine and other mushroom extracts that may have some neuroprotective and antioxidant properties. However, reviews on the effectiveness of Alpha Brain have been mixed, with some users experiencing only mild cognitive improvements.

Stress and Anxiety Reduction

When it comes to stress and anxiety reduction, both Nooceptin and Alpha Brain contain L-theanine as a key ingredient. L-theanine is an amino acid found in green tea, known for providing a relaxed state while maintaining clear mental focus. The inclusion of L-theanine in both supplements may help reduce stress and anxiety levels without causing drowsiness or fatigue.

Nooceptin also contains Rhodiola Rosea, an adaptogenic herb known for its stress-reducing and fatigue-fighting properties, which may contribute to better overall mood and motivation levels.

Memory Retention and Recall

Memory retention and recall are also essential aspects of cognitive performance that both Nooceptin and Alpha Brain aim to address. Nooceptin achieves this through the inclusion of Alpha GPC, a choline precursor that supports the production of acetylcholine – a neurotransmitter essential for learning and memory processes.

Alpha Brain, however, has shown mixed results in its ability to support memory retention and recall. Some studies have found minor improvements in memory function, but the benefits of Alpha Brain are not as consistently reported as those seen with Nooceptin or other cognitive enhancers like Mind Lab Pro and NooCube.

In summary, both Nooceptin and Alpha Brain offer a range of ingredients aimed at enhancing cognitive performance, stress reduction, and memory retention. However, Nooceptin seems to have a more consistent and well-rounded formula providing better results compared to Alpha Brain.

Safety and Side Effects

Side Effects of Nooceptin

Nooceptin is a nootropic that uses natural ingredients to provide cognitive benefits. It contains ingredients like L-tyrosine, phosphatidylserine, and Panax ginseng, which are known for promoting relaxation, creativity, and improving processing speed. As a result, users often experience reduced stress and anxiety levels.

The amino acid L-tyrosine is believed to increase dopamine production, improving mood while reducing oxidative stress. Phosphatidylserine, on the other hand, has been linked to supporting age-related cognitive decline prevention. Panax ginseng, an essential component in traditional Chinese medicine, has long been used for its cognitive-enhancing effects.

Generally, Nooceptin is considered safe because it relies on natural ingredients. However, it’s crucial to follow the recommended doses to minimize the risk of adverse reactions. If you experience any side effects or have concerns about the ingredients, it’s best to consult a healthcare professional.

Side Effects of Alpha Brain

Alpha Brain is another popular nootropic supplement designed to enhance cognitive function. It includes ingredients like alpha-GPC, L-tyrosine, and Huperzine A. While some users report positive effects, others have experienced side effects linked to Alpha Brain’s components.

Alpha-GPC is known for its potential to increase choline levels in the brain, which can result in improved cognitive function and memory. However, it may cause side effects like headaches, dizziness, and gastrointestinal discomfort in some individuals. L-tyrosine, similarly to Nooceptin, is an amino acid that supports dopamine production and can improve mood and reduce stress.

Huperzine A, however, has raised some safety concerns. While it can prevent age-related cognitive decline by inhibiting an enzyme that breaks down a neurotransmitter responsible for learning and memory, it might lead to undesirable side effects like nausea, vomiting, and diarrhea. Moreover, prolonged Huperzine A use might lead to reduced acetylcholine levels in the brain, countering its initial benefits.

In conclusion, both Nooceptin and Alpha Brain claim to offer cognitive benefits and support to users. Nooceptin relies primarily on natural ingredients with fewer reported side effects, while Alpha Brain might have some safety concerns due to the inclusion of Huperzine A. If you decide to try either of these nootropics, it’s essential to follow the recommended doses and consult a healthcare professional for additional guidance.

Pricing and Value

Nooceptin and Alpha Brain are both nootropic supplements designed to enhance cognitive performance, overall brain health, and learning capabilities. When comparing the two products, it’s important to consider their pricing and overall value.

A single bottle of Alpha Brain costs $79.85, which contains 90 capsules. This means the cost per capsule is approximately $0.89. On the other hand, the pricing information for Nooceptin is not readily available, but according to various reviews, it is considered to be more cost-effective compared to Alpha Brain.

When it comes to side effects, Alpha Brain may cause some users to experience mild side effects, such as headaches or gastrointestinal issues. However, these cases seem to be less frequent. Nooceptin has also been reported to have minimal side effects, making it a safer option for most users.

In terms of cognitive performance, Nooceptin is considered to be more effective than Alpha Brain. As mentioned in this review, testers found Nooceptin to be more potent and impactful when it comes to enhancing memory, focus, and overall brain function.

It’s worth noting that the ingredients in both supplements contribute to overall brain health and learning. While Alpha Brain contains popular nootropic ingredients like Bacopa Monnieri and L-theanine, NooCube – a more affordable alternative to Alpha Brain – offers an extensive 250mg per serving. This makes NooCube an attractive option for those seeking similar benefits at a lower price point.

In conclusion, it’s essential to weigh the pricing, side effects, cognitive performance, overall brain health, and learning benefits when choosing between Nooceptin and Alpha Brain. While both supplements aim to offer cognitive enhancement, Nooceptin appears to provide better value for its price, efficacy, and minimal side effects.


In comparing Nooceptin and Alpha Brain, it’s important to consider their respective ingredients and reported effects. Nooceptin has been rated as a top nootropic for its effective blend of ingredients that promote brain health and cognitive function. On the other hand, Alpha Brain has mixed reviews with some users experiencing benefits while others question the effectiveness of certain ingredients in the stack.

When evaluating the long-term benefits and overall impact on cognitive performance, Nooceptin appears to outshine Alpha Brain. Nooceptin’s ingredients have been found to be more conducive to promoting long-term brain health and function, as described in this Alpha Brain ingredients analysis. On the other hand, some users have reported positive short-term effects from taking Alpha Brain, such as improved memory and focus, which might make it more appropriate for temporary cognitive boosts.

In order to make an informed decision, it’s crucial to understand your own cognitive needs, desired benefits, and any potential side effects. While Nooceptin has been reported to work exactly as advertised and with minimal side effects, it’s essential to consider individual experiences and reactions. Similarly, although Alpha Brain may be a popular choice in the nootropics market, it’s important to assess its suitability for your goals and health.

Ultimately, the choice between Nooceptin and Alpha Brain should be based on personal preferences and cognitive goals. However, based on various reviews and analyses of ingredients, Nooceptin appears to be a more effective and reliable option overall for those seeking long-term benefits in cognitive performance and brain health.


Do nootropics work?

Many nootropic ingredients and formulations have been shown to improve attention, memory, and learning, while others may promote relaxation and reduce stress and anxiety. For example, caffeine is a commonly used nootropic that can increase alertness and reduce fatigue, while L-Theanine, an amino acid found in tea leaves, has been shown to promote relaxation and reduce stress.

Are nootropics safe?

Nootropics that contain natural ingredients and have undergone clinical testing are generally considered safe when used properly. It is important to follow recommended dosages and to avoid taking more than the recommended amount. It's also worth being aware of any potential side effects and if necessary consult with your doctor if you have any underlying medical conditions.

What should I expect from a nootropic?

When taking a nootropic supplement, you should expect to experience some improvement in cognitive function, such as enhanced memory, concentration, and mental clarity. The effects of a nootropic will vary depending on the specific ingredients and dosage of the supplement, as well as individual factors such as age, overall health, and your lifestyle.

Which nootropic should I buy?

Popular nootropic supplements include NooCube, Mind Lab Pro, and Vyvamind. NooCube contains a blend of ingredients that may improve memory, focus, and overall cognitive function. Mind Lab Pro is designed to support brain health and cognitive performance through a variety of ingredients, including vitamins, minerals, and plant-based compounds. Vyvamind is a premium nootropic supplement that focuses almost exlcusively on cognitive function and mental performance. Read DBEM's guide to nootropics to see how the leading nootropic brands compare.


  1. Smart Drug Smarts. (2022). Smart Drugs vs. Nootropics. Smart Drug Smarts.
  2. Urban, K. R., & Gao, W. J. (2014). Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brain. Frontiers in Systems Neuroscience. ↩
  3. Lynch, G., Cox, C. D., & Gall, C. M. (2014). Pharmacological enhancement of memory or cognition in normal subjects. Frontiers in Systems Neuroscience. ↩
  4. Kean, J. D., Kaufman, J., Lomas, J. (2017). A systematic review of Bacopa monniera, an herbal medicine, on human cognitive performance. Neuropsychology Review. ↩
  5. Swanson, J. M., & Volkow, N. D. (2003). Serum and brain concentrations of methylphenidate: implications for use and abuse. Neuroscience & Biobehavioral Reviews. ↩
  6. Heal, D. J., Smith, S. L., Gosden, J., & Nutt, D. J. (2013). Amphetamine, past and present – a pharmacological and clinical perspective. Journal of Psychopharmacology. ↩
  7. Bostock, E., Kirkby, K. C., & Taylor, B. (2017). The Current Status of the Ketogenic Diet in Psychiatry. Frontiers in Psychiatry. ↩
  8. Patel, K. (2019). The Nootropic Synergy of L-Theanine and Caffeine. Nootropics Expert. ↩
  9. Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Telang, F. (2011). Addiction: beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences. ↩
  10. Rogers, P. J., & Dernoncourt, C. (1998). Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacology Biochemistry and Behavior. ↩
  11. Meredith, S. E., Juliano, L. M., Hughes, J. R., & Griffiths, R. R. (2013). Caffeine Use Disorder: A Comprehensive Review and Research Agenda. Journal of Caffeine Research. ↩
  12. Jarvis, M. F. (2016). The neural–glial purinergic receptor ensemble in chronic pain states. Trends in Neurosciences. ↩